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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN1 All Species: 9.39
Human Site: S933 Identified Species: 17.22
UniProt: P35523 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35523 NP_000074.2 988 108756 S933 S P E T P V P S P S P E P P L
Chimpanzee Pan troglodytes XP_527935 988 108838 S933 S P E T P V P S P S P E P P L
Rhesus Macaque Macaca mulatta XP_001092282 736 80740 P687 P S P S P E P P L S L A P G K
Dog Lupus familis XP_859634 871 95882 G820 E G S V T A Q G V K V R P P L
Cat Felis silvestris
Mouse Mus musculus Q64347 994 109776 P939 M P E T P V P P P S P E A P S
Rat Rattus norvegicus P35524 994 110055 P939 M P E T P V P P P S P E V P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 L821 M A L E E E S L P S T S S L C
Chicken Gallus gallus XP_425521 996 111070 S934 R S T L P L Y S H S P Q P S H
Frog Xenopus laevis Q9W701 689 76782 L640 I E P V T F Q L S T W T S L H
Zebra Danio Brachydanio rerio XP_695866 879 96751 T830 S A G S C I Q T V E K E C E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 S1140 A V D M T V T S M D S A L S N
Honey Bee Apis mellifera XP_392015 919 102193 K865 V G L K E L R K A I E D A N A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 A730 I L K G L V T A K D I L R F K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 72.4 49.7 N.A. 87.4 87.8 N.A. 63.8 65.8 32.4 56.3 N.A. 34.9 36 N.A. N.A.
Protein Similarity: 100 99.8 72.9 64 N.A. 91.4 91.9 N.A. 71.3 77.1 47.4 68.3 N.A. 51.9 52.4 N.A. N.A.
P-Site Identity: 100 100 26.6 20 N.A. 73.3 73.3 N.A. 13.3 33.3 0 13.3 N.A. 13.3 0 N.A. N.A.
P-Site Similarity: 100 100 33.3 20 N.A. 73.3 73.3 N.A. 13.3 46.6 6.6 33.3 N.A. 26.6 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 0 0 0 8 0 8 8 0 0 16 16 0 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 8 % C
% Asp: 0 0 8 0 0 0 0 0 0 16 0 8 0 0 0 % D
% Glu: 8 8 31 8 16 16 0 0 0 8 8 39 0 8 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 16 8 8 0 0 0 8 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 16 % H
% Ile: 16 0 0 0 0 8 0 0 0 8 8 0 0 0 0 % I
% Lys: 0 0 8 8 0 0 0 8 8 8 8 0 0 0 16 % K
% Leu: 0 8 16 8 8 16 0 16 8 0 8 8 8 16 24 % L
% Met: 24 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % N
% Pro: 8 31 16 0 47 0 39 24 39 0 39 0 39 39 0 % P
% Gln: 0 0 0 0 0 0 24 0 0 0 0 8 0 0 0 % Q
% Arg: 8 0 0 0 0 0 8 0 0 0 0 8 8 0 0 % R
% Ser: 24 16 8 16 0 0 8 31 8 54 8 8 16 16 24 % S
% Thr: 0 0 8 31 24 0 16 8 0 8 8 8 0 0 0 % T
% Val: 8 8 0 16 0 47 0 0 16 0 8 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _