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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLCN1
All Species:
21.82
Human Site:
S974
Identified Species:
40
UniProt:
P35523
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35523
NP_000074.2
988
108756
S974
A
D
I
L
Q
G
P
S
L
R
S
T
D
E
E
Chimpanzee
Pan troglodytes
XP_527935
988
108838
S974
A
D
I
L
Q
G
P
S
L
R
S
T
D
E
E
Rhesus Macaque
Macaca mulatta
XP_001092282
736
80740
S725
L
Q
G
P
S
L
R
S
T
D
E
E
D
E
D
Dog
Lupus familis
XP_859634
871
95882
E860
S
H
H
G
L
P
R
E
G
S
P
S
D
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q64347
994
109776
S980
A
D
I
L
H
G
P
S
L
R
S
T
D
E
E
Rat
Rattus norvegicus
P35524
994
110055
S980
A
D
I
L
H
G
P
S
L
R
S
T
D
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506417
871
95443
R860
R
C
R
A
K
L
D
R
E
P
N
V
G
E
G
Chicken
Gallus gallus
XP_425521
996
111070
S980
S
D
I
L
K
D
I
S
L
H
S
T
D
L
D
Frog
Xenopus laevis
Q9W701
689
76782
M678
G
Q
V
T
R
K
E
M
K
K
A
I
E
D
L
Zebra Danio
Brachydanio rerio
XP_695866
879
96751
G868
H
S
V
P
G
G
E
G
D
A
E
K
E
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VGH7
1193
133629
S1181
Q
E
S
K
Q
S
P
S
A
D
K
S
N
T
E
Honey Bee
Apis mellifera
XP_392015
919
102193
S907
K
N
V
S
T
M
N
S
I
A
S
V
D
C
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P37020
779
87664
K768
S
V
I
H
F
I
I
K
R
F
T
T
N
R
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
72.4
49.7
N.A.
87.4
87.8
N.A.
63.8
65.8
32.4
56.3
N.A.
34.9
36
N.A.
N.A.
Protein Similarity:
100
99.8
72.9
64
N.A.
91.4
91.9
N.A.
71.3
77.1
47.4
68.3
N.A.
51.9
52.4
N.A.
N.A.
P-Site Identity:
100
100
20
6.6
N.A.
93.3
93.3
N.A.
6.6
53.3
0
6.6
N.A.
26.6
26.6
N.A.
N.A.
P-Site Similarity:
100
100
26.6
26.6
N.A.
93.3
93.3
N.A.
20
73.3
40
26.6
N.A.
46.6
46.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
0
8
0
0
0
0
8
16
8
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
39
0
0
0
8
8
0
8
16
0
0
62
8
31
% D
% Glu:
0
8
0
0
0
0
16
8
8
0
16
8
16
47
47
% E
% Phe:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
0
8
8
8
39
0
8
8
0
0
0
8
0
8
% G
% His:
8
8
8
8
16
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
47
0
0
8
16
0
8
0
0
8
0
0
0
% I
% Lys:
8
0
0
8
16
8
0
8
8
8
8
8
0
0
0
% K
% Leu:
8
0
0
39
8
16
0
0
39
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
8
0
0
0
8
0
16
0
8
% N
% Pro:
0
0
0
16
0
8
39
0
0
8
8
0
0
0
0
% P
% Gln:
8
16
0
0
24
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
8
0
8
0
16
8
8
31
0
0
0
16
0
% R
% Ser:
24
8
8
8
8
8
0
62
0
8
47
16
0
8
0
% S
% Thr:
0
0
0
8
8
0
0
0
8
0
8
47
0
8
0
% T
% Val:
0
8
24
0
0
0
0
0
0
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _