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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN1 All Species: 21.82
Human Site: S974 Identified Species: 40
UniProt: P35523 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35523 NP_000074.2 988 108756 S974 A D I L Q G P S L R S T D E E
Chimpanzee Pan troglodytes XP_527935 988 108838 S974 A D I L Q G P S L R S T D E E
Rhesus Macaque Macaca mulatta XP_001092282 736 80740 S725 L Q G P S L R S T D E E D E D
Dog Lupus familis XP_859634 871 95882 E860 S H H G L P R E G S P S D S D
Cat Felis silvestris
Mouse Mus musculus Q64347 994 109776 S980 A D I L H G P S L R S T D E E
Rat Rattus norvegicus P35524 994 110055 S980 A D I L H G P S L R S T D E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 R860 R C R A K L D R E P N V G E G
Chicken Gallus gallus XP_425521 996 111070 S980 S D I L K D I S L H S T D L D
Frog Xenopus laevis Q9W701 689 76782 M678 G Q V T R K E M K K A I E D L
Zebra Danio Brachydanio rerio XP_695866 879 96751 G868 H S V P G G E G D A E K E R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 S1181 Q E S K Q S P S A D K S N T E
Honey Bee Apis mellifera XP_392015 919 102193 S907 K N V S T M N S I A S V D C E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 K768 S V I H F I I K R F T T N R N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 72.4 49.7 N.A. 87.4 87.8 N.A. 63.8 65.8 32.4 56.3 N.A. 34.9 36 N.A. N.A.
Protein Similarity: 100 99.8 72.9 64 N.A. 91.4 91.9 N.A. 71.3 77.1 47.4 68.3 N.A. 51.9 52.4 N.A. N.A.
P-Site Identity: 100 100 20 6.6 N.A. 93.3 93.3 N.A. 6.6 53.3 0 6.6 N.A. 26.6 26.6 N.A. N.A.
P-Site Similarity: 100 100 26.6 26.6 N.A. 93.3 93.3 N.A. 20 73.3 40 26.6 N.A. 46.6 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 31 0 0 8 0 0 0 0 8 16 8 0 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 39 0 0 0 8 8 0 8 16 0 0 62 8 31 % D
% Glu: 0 8 0 0 0 0 16 8 8 0 16 8 16 47 47 % E
% Phe: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 8 0 8 8 8 39 0 8 8 0 0 0 8 0 8 % G
% His: 8 8 8 8 16 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 0 47 0 0 8 16 0 8 0 0 8 0 0 0 % I
% Lys: 8 0 0 8 16 8 0 8 8 8 8 8 0 0 0 % K
% Leu: 8 0 0 39 8 16 0 0 39 0 0 0 0 8 8 % L
% Met: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 8 0 0 0 8 0 16 0 8 % N
% Pro: 0 0 0 16 0 8 39 0 0 8 8 0 0 0 0 % P
% Gln: 8 16 0 0 24 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 8 0 8 0 16 8 8 31 0 0 0 16 0 % R
% Ser: 24 8 8 8 8 8 0 62 0 8 47 16 0 8 0 % S
% Thr: 0 0 0 8 8 0 0 0 8 0 8 47 0 8 0 % T
% Val: 0 8 24 0 0 0 0 0 0 0 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _