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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN1 All Species: 8.79
Human Site: T735 Identified Species: 16.11
UniProt: P35523 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35523 NP_000074.2 988 108756 T735 S L A L H P S T T A P L S P E
Chimpanzee Pan troglodytes XP_527935 988 108838 T735 S L P L H P S T T A P L S P E
Rhesus Macaque Macaca mulatta XP_001092282 736 80740 P506 H K Q Q P E A P E P A G Q R P
Dog Lupus familis XP_859634 871 95882 Y639 S P A R R R Q Y M Q E R R A A
Cat Felis silvestris
Mouse Mus musculus Q64347 994 109776 S732 T P A P P P P S P P P P P S Q
Rat Rattus norvegicus P35524 994 110055 P732 T P T P P P P P P P P L P P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 L639 Y R D L Q A L L H V T T A K T
Chicken Gallus gallus XP_425521 996 111070 E740 P S P S H P E E P N G P T N P
Frog Xenopus laevis Q9W701 689 76782 I459 E G I A A D G I V N P I I P G
Zebra Danio Brachydanio rerio XP_695866 879 96751 G643 E E C N G P V G S S K T T D I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 P876 E V E V P R T P S T P G V S K
Honey Bee Apis mellifera XP_392015 919 102193 A682 T M S P S N G A H T Y H S P I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 S549 A I T R I I L S T S G I S G G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 72.4 49.7 N.A. 87.4 87.8 N.A. 63.8 65.8 32.4 56.3 N.A. 34.9 36 N.A. N.A.
Protein Similarity: 100 99.8 72.9 64 N.A. 91.4 91.9 N.A. 71.3 77.1 47.4 68.3 N.A. 51.9 52.4 N.A. N.A.
P-Site Identity: 100 93.3 0 13.3 N.A. 20 26.6 N.A. 6.6 13.3 13.3 6.6 N.A. 6.6 13.3 N.A. N.A.
P-Site Similarity: 100 93.3 6.6 13.3 N.A. 40 40 N.A. 13.3 20 20 26.6 N.A. 40 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 24 8 8 8 8 8 0 16 8 0 8 8 8 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 8 0 0 0 0 0 0 0 8 0 % D
% Glu: 24 8 8 0 0 8 8 8 8 0 8 0 0 0 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 8 0 16 8 0 0 16 16 0 8 16 % G
% His: 8 0 0 0 24 0 0 0 16 0 0 8 0 0 0 % H
% Ile: 0 8 8 0 8 8 0 8 0 0 0 16 8 0 16 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 8 0 0 8 8 % K
% Leu: 0 16 0 24 0 0 16 8 0 0 0 24 0 0 0 % L
% Met: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 0 0 16 0 0 0 8 0 % N
% Pro: 8 24 16 24 31 47 16 24 24 24 47 16 16 39 16 % P
% Gln: 0 0 8 8 8 0 8 0 0 8 0 0 8 0 16 % Q
% Arg: 0 8 0 16 8 16 0 0 0 0 0 8 8 8 0 % R
% Ser: 24 8 8 8 8 0 16 16 16 16 0 0 31 16 0 % S
% Thr: 24 0 16 0 0 0 8 16 24 16 8 16 16 0 8 % T
% Val: 0 8 0 8 0 0 8 0 8 8 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _