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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLCN1
All Species:
29.39
Human Site:
Y589
Identified Species:
53.89
UniProt:
P35523
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35523
NP_000074.2
988
108756
Y589
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Chimpanzee
Pan troglodytes
XP_527935
988
108838
Y589
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Rhesus Macaque
Macaca mulatta
XP_001092282
736
80740
Q378
G
E
L
R
T
L
L
Q
T
T
T
V
K
T
L
Dog
Lupus familis
XP_859634
871
95882
V510
T
H
T
V
S
T
A
V
I
V
F
E
L
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64347
994
109776
Y589
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Rat
Rattus norvegicus
P35524
994
110055
Y589
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506417
871
95443
E510
A
F
G
R
L
V
G
E
I
M
A
V
L
F
P
Chicken
Gallus gallus
XP_425521
996
111070
Y597
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Frog
Xenopus laevis
Q9W701
689
76782
L331
D
K
P
M
Y
S
A
L
V
A
L
L
I
S
S
Zebra Danio
Brachydanio rerio
XP_695866
879
96751
Y515
I
Q
V
K
K
L
P
Y
L
P
E
L
G
I
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VGH7
1193
133629
Y643
I
L
I
K
K
L
P
Y
L
P
D
L
L
P
S
Honey Bee
Apis mellifera
XP_392015
919
102193
Y538
I
L
I
K
K
L
P
Y
L
P
D
L
L
P
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P37020
779
87664
F421
K
N
D
N
T
S
T
F
S
H
R
L
C
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
72.4
49.7
N.A.
87.4
87.8
N.A.
63.8
65.8
32.4
56.3
N.A.
34.9
36
N.A.
N.A.
Protein Similarity:
100
99.8
72.9
64
N.A.
91.4
91.9
N.A.
71.3
77.1
47.4
68.3
N.A.
51.9
52.4
N.A.
N.A.
P-Site Identity:
100
100
6.6
0
N.A.
100
100
N.A.
0
100
6.6
80
N.A.
66.6
66.6
N.A.
N.A.
P-Site Similarity:
100
100
33.3
6.6
N.A.
100
100
N.A.
33.3
100
26.6
86.6
N.A.
80
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
16
0
0
8
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
8
0
8
0
0
0
0
0
0
0
54
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
8
0
0
8
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
8
0
0
8
0
0
8
0
% F
% Gly:
8
0
8
0
0
0
8
0
0
0
0
0
47
0
16
% G
% His:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
62
0
16
0
0
0
0
0
16
0
0
0
8
8
0
% I
% Lys:
8
8
0
62
62
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
16
8
0
8
70
8
8
62
0
8
77
31
0
16
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
39
% N
% Pro:
0
0
8
0
0
0
62
0
0
62
0
0
0
16
8
% P
% Gln:
0
47
0
0
0
0
0
8
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
16
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
0
8
16
0
0
8
0
0
0
0
8
24
% S
% Thr:
8
0
8
0
16
8
8
0
8
8
8
0
0
16
0
% T
% Val:
0
0
47
8
0
8
0
8
8
8
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
39
0
% W
% Tyr:
0
0
0
0
8
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _