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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GCK
All Species:
13.33
Human Site:
Y349
Identified Species:
24.44
UniProt:
P35557
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35557
NP_000153.1
465
52191
Y349
T
G
D
R
K
Q
I
Y
N
I
L
S
T
L
G
Chimpanzee
Pan troglodytes
XP_001143661
465
52172
Y349
T
G
D
R
K
Q
I
Y
N
I
L
S
T
L
G
Rhesus Macaque
Macaca mulatta
XP_001093035
458
51285
Y342
T
G
D
R
K
Q
I
Y
N
I
L
S
T
L
G
Dog
Lupus familis
XP_532991
909
101134
R793
C
L
A
L
L
Q
V
R
A
I
L
H
H
L
G
Cat
Felis silvestris
Mouse
Mus musculus
P52792
465
52070
L349
S
G
D
R
R
Q
I
L
N
I
L
S
T
L
G
Rat
Rattus norvegicus
P17712
465
52098
H349
S
G
D
R
K
Q
I
H
N
I
L
S
T
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520120
593
65484
Y387
C
G
D
R
K
Q
I
Y
N
L
L
S
T
L
G
Chicken
Gallus gallus
NP_989543
916
102399
R801
C
L
A
L
L
Q
V
R
S
I
L
Q
H
L
G
Frog
Xenopus laevis
NP_001079298
458
51069
L342
T
S
D
F
K
Q
T
L
N
I
L
R
T
L
G
Zebra Danio
Brachydanio rerio
NP_998231
919
102145
E355
D
E
G
I
V
S
A
E
Q
V
L
R
G
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NFT7
486
53467
C375
A
P
G
E
Y
R
N
C
N
K
V
L
S
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42525
496
53688
K379
K
I
V
G
S
K
I
K
D
I
L
E
V
P
T
Baker's Yeast
Sacchar. cerevisiae
P04807
486
53924
L364
N
L
E
D
T
D
D
L
F
Q
N
E
F
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
30.7
N.A.
95.9
96.9
N.A.
71.8
30.2
79.3
28.8
N.A.
40.9
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.2
39.4
N.A.
98.2
98.7
N.A.
75.3
39.9
89.8
39
N.A.
62.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
33.3
N.A.
80
86.6
N.A.
86.6
33.3
66.6
20
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
40
N.A.
93.3
100
N.A.
93.3
46.6
66.6
26.6
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.4
28.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53
53.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
0
0
0
8
0
8
0
0
0
0
0
0
% A
% Cys:
24
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
54
8
0
8
8
0
8
0
0
0
0
0
0
% D
% Glu:
0
8
8
8
0
0
0
8
0
0
0
16
0
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
8
0
0
0
8
0
0
% F
% Gly:
0
47
16
8
0
0
0
0
0
0
0
0
8
8
77
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
8
16
0
0
% H
% Ile:
0
8
0
8
0
0
54
0
0
70
0
0
0
0
8
% I
% Lys:
8
0
0
0
47
8
0
8
0
8
0
0
0
0
0
% K
% Leu:
0
24
0
16
16
0
0
24
0
8
85
8
0
77
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
8
0
62
0
8
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
70
0
0
8
8
0
8
0
0
0
% Q
% Arg:
0
0
0
47
8
8
0
16
0
0
0
16
0
0
0
% R
% Ser:
16
8
0
0
8
8
0
0
8
0
0
47
8
0
0
% S
% Thr:
31
0
0
0
8
0
8
0
0
0
0
0
54
0
8
% T
% Val:
0
0
8
0
8
0
16
0
0
8
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _