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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRS1
All Species:
28.79
Human Site:
S1231
Identified Species:
57.58
UniProt:
P35568
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35568
NP_005535.1
1242
131591
S1231
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
Chimpanzee
Pan troglodytes
XP_001134895
1241
131474
S1230
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
Rhesus Macaque
Macaca mulatta
XP_001109882
1252
133053
S1241
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
Dog
Lupus familis
XP_543274
1180
124676
S1169
E
D
L
S
A
Y
A
S
I
S
F
Q
K
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
P35569
1233
130705
S1222
E
D
L
S
N
Y
A
S
I
S
F
Q
K
Q
P
Rat
Rattus norvegicus
P35570
1235
131160
S1224
E
D
L
S
T
Y
A
S
I
N
F
Q
K
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505439
368
40215
S359
L
S
A
Y
A
S
I
S
F
Q
K
P
P
E
D
Chicken
Gallus gallus
NP_001026741
1240
131795
S1229
E
D
L
S
A
Y
A
S
T
S
F
Q
K
Q
P
Frog
Xenopus laevis
P84770
1088
119088
E1079
I
T
F
H
K
L
E
E
H
R
S
Q
A
E
T
Zebra Danio
Brachydanio rerio
XP_687702
1136
122765
E1127
C
P
G
T
K
G
G
E
E
L
R
V
R
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9XTN2
968
107813
S959
D
F
D
Q
S
D
S
S
S
S
S
S
N
I
F
Honey Bee
Apis mellifera
XP_391985
1190
129451
K1181
Q
E
G
F
N
Y
A
K
I
D
F
A
K
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.5
87.5
N.A.
89.5
89.7
N.A.
26.4
91.2
59.9
52.2
N.A.
20.6
20.4
N.A.
N.A.
Protein Similarity:
100
99.2
98
89.4
N.A.
92.3
92.2
N.A.
28
92.9
67.6
61.3
N.A.
37.6
37.3
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
86.6
N.A.
13.3
93.3
6.6
0
N.A.
13.3
33.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
20
93.3
13.3
13.3
N.A.
33.3
46.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
50
0
67
0
0
0
0
9
9
0
0
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
59
9
0
0
9
0
0
0
9
0
0
0
0
9
% D
% Glu:
59
9
0
0
0
0
9
17
9
0
0
0
0
17
0
% E
% Phe:
0
9
9
9
0
0
0
0
9
0
67
0
0
0
9
% F
% Gly:
0
0
17
0
0
9
9
0
0
0
0
0
0
0
9
% G
% His:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
9
0
59
0
0
0
0
9
0
% I
% Lys:
0
0
0
0
17
0
0
9
0
0
9
0
67
0
9
% K
% Leu:
9
0
59
0
0
9
0
0
0
9
0
0
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
17
0
0
0
0
9
0
0
9
0
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
9
9
9
59
% P
% Gln:
9
0
0
9
0
0
0
0
0
9
0
67
0
59
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
9
9
0
9
0
0
% R
% Ser:
0
9
0
59
9
9
9
75
9
59
17
9
0
0
0
% S
% Thr:
0
9
0
9
9
0
0
0
9
0
0
0
0
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
67
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _