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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TIE1 All Species: 29.7
Human Site: S1028 Identified Species: 59.39
UniProt: P35590 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35590 NP_005415.1 1138 125090 S1028 A I E S L N Y S V Y T T K S D
Chimpanzee Pan troglodytes XP_001173341 1138 125051 S1028 A I E S L N Y S V Y T T K S D
Rhesus Macaque Macaca mulatta XP_001090483 1164 128010 S1054 A I E S L N Y S V Y T T K S D
Dog Lupus familis XP_539652 1239 135146 S1129 A I E S L N Y S V Y T T K S D
Cat Felis silvestris
Mouse Mus musculus Q06806 1134 124680 S1024 A I E S L N Y S V Y T T K S D
Rat Rattus norvegicus Q498D6 800 88690 S698 I P V E E L F S L L R E G H R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512741 1077 116365 S966 A I E S L N Y S V Y T T K S D
Chicken Gallus gallus P18460 806 89712 G704 L F K L L K E G H R M D K P A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio O73791 1116 122343 S1005 A I E S L N Y S V Y T T N S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VBW3 773 86202 W671 F S V K S D I W S F G I L M W
Honey Bee Apis mellifera XP_396649 796 90178 G694 W E I M T L G G T P Y P S V P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus Q26614 972 110463 Y870 P V E Q M F D Y L R S G K R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.1 85.6 N.A. 92.5 25.8 N.A. 65.9 25.1 N.A. 44.6 N.A. 22.4 24.7 N.A. 22.8
Protein Similarity: 100 99.8 96.2 88.1 N.A. 95.5 37.9 N.A. 74.3 39.3 N.A. 58.7 N.A. 36 40.3 N.A. 39.1
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 100 13.3 N.A. 93.3 N.A. 0 0 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 100 20 N.A. 93.3 N.A. 13.3 0 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 59 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 9 0 0 0 0 9 0 0 59 % D
% Glu: 0 9 67 9 9 0 9 0 0 0 0 9 0 0 0 % E
% Phe: 9 9 0 0 0 9 9 0 0 9 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 9 17 0 0 9 9 9 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % H
% Ile: 9 59 9 0 0 0 9 0 0 0 0 9 0 0 0 % I
% Lys: 0 0 9 9 0 9 0 0 0 0 0 0 67 0 0 % K
% Leu: 9 0 0 9 67 17 0 0 17 9 0 0 9 0 9 % L
% Met: 0 0 0 9 9 0 0 0 0 0 9 0 0 9 0 % M
% Asn: 0 0 0 0 0 59 0 0 0 0 0 0 9 0 0 % N
% Pro: 9 9 0 0 0 0 0 0 0 9 0 9 0 9 9 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 17 9 0 0 9 9 % R
% Ser: 0 9 0 59 9 0 0 67 9 0 9 0 9 59 0 % S
% Thr: 0 0 0 0 9 0 0 0 9 0 59 59 0 0 0 % T
% Val: 0 9 17 0 0 0 0 0 59 0 0 0 0 9 0 % V
% Trp: 9 0 0 0 0 0 0 9 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 0 0 0 59 9 0 59 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _