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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIMP3
All Species:
18.18
Human Site:
Y137
Identified Species:
36.36
UniProt:
P35625
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35625
NP_000353.1
211
24145
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Chimpanzee
Pan troglodytes
XP_516284
224
25530
H150
V
Q
R
E
S
L
N
H
H
Y
H
L
N
C
G
Rhesus Macaque
Macaca mulatta
Q95KL9
207
23229
L133
A
P
W
N
S
L
S
L
A
Q
R
R
G
F
T
Dog
Lupus familis
XP_538410
211
24134
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Cat
Felis silvestris
Mouse
Mus musculus
P39876
211
24164
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Rat
Rattus norvegicus
P48032
211
24208
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509154
355
40199
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Chicken
Gallus gallus
P26652
212
24486
H138
S
Q
R
K
G
L
N
H
R
Y
H
L
G
C
G
Frog
Xenopus laevis
O73746
214
24437
H140
A
Q
R
K
G
L
N
H
R
Y
P
L
G
C
T
Zebra Danio
Brachydanio rerio
NP_878294
220
24449
Q146
T
Q
K
K
S
L
S
Q
R
Y
Q
M
G
C
D
Tiger Blowfish
Takifugu rubipres
NP_001033042
214
24704
H140
A
Q
K
K
G
F
N
H
R
Y
Q
L
G
C
N
Fruit Fly
Dros. melanogaster
Q9VH14
210
23961
G137
T
E
R
H
G
F
S
G
G
Y
A
K
A
T
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.7
37.9
99
N.A.
96.2
95.2
N.A.
53.5
80.6
78
43.6
69.6
23.7
N.A.
N.A.
N.A.
Protein Similarity:
100
66
56.4
99.5
N.A.
97.6
96.6
N.A.
57.1
90.5
88.7
64.5
83.1
45.9
N.A.
N.A.
N.A.
P-Site Identity:
100
53.3
13.3
100
N.A.
100
100
N.A.
100
86.6
73.3
46.6
66.6
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
66.6
26.6
100
N.A.
100
100
N.A.
100
93.3
86.6
80
86.6
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
0
0
0
0
0
0
9
0
9
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
84
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
17
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
75
0
0
9
9
0
0
0
84
0
17
% G
% His:
0
0
0
9
0
0
0
34
9
0
59
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
17
75
0
0
0
0
0
0
0
9
0
0
0
% K
% Leu:
0
0
0
0
0
84
0
9
0
0
0
75
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
0
9
0
0
75
0
0
0
0
0
9
0
59
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% P
% Gln:
0
84
0
0
0
0
0
9
0
9
17
0
0
0
0
% Q
% Arg:
0
0
75
0
0
0
0
0
75
0
9
9
0
0
0
% R
% Ser:
50
0
0
0
25
0
25
0
0
0
0
0
0
0
0
% S
% Thr:
17
0
0
0
0
0
0
0
0
0
0
0
0
9
17
% T
% Val:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
42
0
92
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _