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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIMP3
All Species:
30
Human Site:
Y177
Identified Species:
60
UniProt:
P35625
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35625
NP_000353.1
211
24145
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Chimpanzee
Pan troglodytes
XP_516284
224
25530
Y190
L
E
R
K
L
Y
G
Y
Q
A
Q
H
Y
V
C
Rhesus Macaque
Macaca mulatta
Q95KL9
207
23229
Q173
T
H
C
L
W
T
D
Q
L
L
Q
G
S
E
K
Dog
Lupus familis
XP_538410
211
24134
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Cat
Felis silvestris
Mouse
Mus musculus
P39876
211
24164
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Rat
Rattus norvegicus
P48032
211
24208
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509154
355
40199
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Chicken
Gallus gallus
P26652
212
24486
H178
S
N
F
G
H
S
G
H
Q
A
K
H
Y
A
C
Frog
Xenopus laevis
O73746
214
24437
Y180
S
N
F
G
Y
P
G
Y
Q
S
K
N
Y
A
C
Zebra Danio
Brachydanio rerio
NP_878294
220
24449
R186
T
E
K
I
I
H
G
R
Q
S
D
H
Y
A
C
Tiger Blowfish
Takifugu rubipres
NP_001033042
214
24704
Y180
S
N
L
G
Y
P
G
Y
Q
S
R
H
Y
A
C
Fruit Fly
Dros. melanogaster
Q9VH14
210
23961
Y177
F
G
K
C
E
T
N
Y
S
A
C
M
P
H
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.7
37.9
99
N.A.
96.2
95.2
N.A.
53.5
80.6
78
43.6
69.6
23.7
N.A.
N.A.
N.A.
Protein Similarity:
100
66
56.4
99.5
N.A.
97.6
96.6
N.A.
57.1
90.5
88.7
64.5
83.1
45.9
N.A.
N.A.
N.A.
P-Site Identity:
100
40
0
100
N.A.
100
100
N.A.
100
73.3
93.3
46.6
86.6
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
26.6
100
N.A.
100
100
N.A.
100
93.3
100
53.3
93.3
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
25
0
0
0
75
0
% A
% Cys:
0
0
9
9
0
0
0
0
0
0
9
0
0
0
84
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% D
% Glu:
0
17
0
0
9
0
0
0
0
0
0
0
0
9
0
% E
% Phe:
9
0
59
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
67
0
0
84
0
0
0
0
9
0
0
0
% G
% His:
0
9
0
0
9
9
0
9
0
0
0
75
0
9
0
% H
% Ile:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
17
9
0
0
0
0
0
0
59
0
0
0
17
% K
% Leu:
9
0
9
9
9
0
0
0
9
9
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
67
0
0
0
0
9
0
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
59
0
0
0
0
0
0
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
84
0
17
0
0
0
0
% Q
% Arg:
0
0
9
0
0
0
0
9
0
0
9
0
0
0
0
% R
% Ser:
67
0
0
0
0
9
0
0
9
67
0
0
9
0
0
% S
% Thr:
17
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
59
9
0
75
0
0
0
0
84
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _