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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF1B
All Species:
10.3
Human Site:
S325
Identified Species:
25.19
UniProt:
P35680
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35680
NP_000449.1
557
61324
S325
Y
S
S
N
Q
T
H
S
L
N
P
L
L
S
H
Chimpanzee
Pan troglodytes
XP_523618
557
61292
S325
Y
S
S
N
Q
T
H
S
L
N
P
L
L
S
H
Rhesus Macaque
Macaca mulatta
XP_001112223
557
61271
S325
Y
S
S
N
Q
T
H
S
L
N
P
L
L
S
H
Dog
Lupus familis
XP_852994
569
62756
L326
S
S
N
Q
T
H
N
L
N
P
L
L
S
H
G
Cat
Felis silvestris
Mouse
Mus musculus
P27889
558
61569
L326
S
S
N
Q
T
H
N
L
N
P
L
L
T
H
G
Rat
Rattus norvegicus
P23899
557
61352
N325
Y
S
S
N
Q
T
H
N
L
N
P
L
L
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509401
497
55478
H266
N
P
I
S
L
H
Y
H
S
F
L
S
P
S
P
Chicken
Gallus gallus
Q90867
634
69171
V319
P
A
L
S
P
T
K
V
H
G
V
R
Y
N
Q
Frog
Xenopus laevis
Q91910
561
62325
L327
G
P
S
H
P
H
N
L
N
S
L
L
S
H
G
Zebra Danio
Brachydanio rerio
A1L1N5
559
61320
S328
K
L
A
M
D
A
Y
S
G
P
A
H
S
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.2
95.2
N.A.
96.2
97.1
N.A.
61.2
54.2
85.7
81.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
99.8
96.4
N.A.
98.5
98.9
N.A.
69.4
64.5
92.3
89.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
13.3
86.6
N.A.
6.6
6.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
26.6
100
N.A.
20
26.6
33.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
10
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
10
10
0
0
0
0
30
% G
% His:
0
0
0
10
0
40
40
10
10
0
0
10
0
30
40
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
10
0
10
0
0
30
40
0
40
70
40
10
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
20
40
0
0
30
10
30
40
0
0
0
10
10
% N
% Pro:
10
20
0
0
20
0
0
0
0
30
40
0
10
0
10
% P
% Gln:
0
0
0
20
40
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
20
60
50
20
0
0
0
40
10
10
0
10
30
40
0
% S
% Thr:
0
0
0
0
20
50
0
0
0
0
0
0
10
10
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
40
0
0
0
0
0
20
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _