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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGFALS
All Species:
21.52
Human Site:
Y248
Identified Species:
47.33
UniProt:
P35858
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35858
NP_004961.1
605
66035
Y248
L
P
R
L
Q
K
L
Y
L
D
R
N
L
I
A
Chimpanzee
Pan troglodytes
XP_001172738
551
60084
R243
N
V
F
V
Q
L
P
R
L
Q
K
L
Y
L
D
Rhesus Macaque
Macaca mulatta
XP_001118634
605
66157
Y248
L
P
R
L
Q
K
L
Y
L
D
R
N
L
I
A
Dog
Lupus familis
XP_547189
676
72722
Y319
L
P
K
L
Q
K
L
Y
L
D
H
N
V
I
A
Cat
Felis silvestris
Mouse
Mus musculus
P70389
603
66941
Y248
L
P
R
L
Q
K
L
Y
L
D
R
N
L
I
T
Rat
Rattus norvegicus
P35859
603
66793
Y248
L
P
R
L
Q
K
L
Y
L
D
R
N
L
I
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520129
641
68655
F282
L
P
R
L
Q
K
L
F
L
R
G
N
Q
L
S
Chicken
Gallus gallus
XP_425222
574
65481
S232
R
A
F
M
G
M
K
S
L
R
W
L
D
L
S
Frog
Xenopus laevis
NP_001093366
604
67641
Y244
Q
Q
K
T
Q
K
L
Y
L
N
H
N
H
I
S
Zebra Danio
Brachydanio rerio
Q66HV9
622
70428
E247
L
Y
R
L
K
I
L
E
I
A
N
W
P
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12024
1315
151964
D482
V
R
G
L
K
R
L
D
F
S
E
N
G
I
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.2
95.2
68.6
N.A.
77.8
77.5
N.A.
60.2
58.8
55.7
21.7
N.A.
20.6
N.A.
N.A.
N.A.
Protein Similarity:
100
90.5
97.1
76.3
N.A.
84.3
85.6
N.A.
70.8
71.9
70
36.9
N.A.
31.4
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
100
80
N.A.
93.3
93.3
N.A.
60
6.6
46.6
26.6
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
100
93.3
N.A.
93.3
93.3
N.A.
80
26.6
66.6
46.6
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
28
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
46
0
0
10
0
10
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% E
% Phe:
0
0
19
0
0
0
0
10
10
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
10
0
0
0
0
0
10
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
19
0
10
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
10
0
0
0
0
64
0
% I
% Lys:
0
0
19
0
19
64
10
0
0
0
10
0
0
0
0
% K
% Leu:
64
0
0
73
0
10
82
0
82
0
0
19
37
37
10
% L
% Met:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
10
10
73
0
0
0
% N
% Pro:
0
55
0
0
0
0
10
0
0
0
0
0
10
0
0
% P
% Gln:
10
10
0
0
73
0
0
0
0
10
0
0
10
0
0
% Q
% Arg:
10
10
55
0
0
10
0
10
0
19
37
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
37
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
19
% T
% Val:
10
10
0
10
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
55
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _