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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6B
All Species:
30.61
Human Site:
Y170
Identified Species:
51.79
UniProt:
P35913
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35913
NP_000274.2
854
98336
Y170
F
A
D
E
L
T
D
Y
K
T
K
N
M
L
A
Chimpanzee
Pan troglodytes
XP_518030
860
99527
Y172
F
V
D
I
L
T
E
Y
K
T
K
N
I
L
A
Rhesus Macaque
Macaca mulatta
XP_001094732
854
97937
Y170
F
A
D
E
L
T
D
Y
K
T
K
N
I
L
A
Dog
Lupus familis
XP_543934
846
97567
P168
T
K
N
L
M
A
T
P
I
V
M
G
K
E
V
Cat
Felis silvestris
Mouse
Mus musculus
P23440
856
98483
Y170
F
A
D
E
L
T
D
Y
V
T
K
N
I
C
S
Rat
Rattus norvegicus
Q8VID6
935
104553
V243
D
R
C
S
L
F
L
V
E
G
A
A
A
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512709
856
98818
Y170
F
A
D
E
T
T
D
Y
V
T
R
N
I
L
A
Chicken
Gallus gallus
P52731
862
99990
Y174
Y
L
D
K
K
T
G
Y
T
T
V
N
M
M
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685002
854
98605
Y171
F
V
D
E
L
T
E
Y
T
T
H
N
L
L
A
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
N206
F
L
V
E
G
T
G
N
K
K
T
L
V
S
K
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
Y360
E
I
D
L
K
T
G
Y
K
T
N
A
I
L
C
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y299
S
I
D
M
R
T
G
Y
K
T
T
L
I
L
S
Nematode Worm
Caenorhab. elegans
P91119
710
81117
R109
D
E
G
A
F
S
C
R
K
T
E
N
G
E
L
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y230
E
V
D
K
I
T
G
Y
K
T
H
S
I
M
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.4
93.9
63.8
N.A.
92.5
24.9
N.A.
86.2
64.5
N.A.
76.1
24.2
23.7
25.6
23.8
32.9
Protein Similarity:
100
82.3
96.7
79.1
N.A.
96.2
44.1
N.A.
92.6
78.8
N.A.
85.1
43.7
41.2
44.6
42.3
53.2
P-Site Identity:
100
73.3
93.3
0
N.A.
73.3
6.6
N.A.
73.3
46.6
N.A.
66.6
26.6
40
40
20
33.3
P-Site Similarity:
100
86.6
100
13.3
N.A.
86.6
13.3
N.A.
86.6
66.6
N.A.
80
33.3
46.6
53.3
33.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
29
0
8
0
8
0
0
0
0
8
15
8
0
43
% A
% Cys:
0
0
8
0
0
0
8
0
0
0
0
0
0
8
15
% C
% Asp:
15
0
72
0
0
0
29
0
0
0
0
0
0
0
0
% D
% Glu:
15
8
0
43
0
0
15
0
8
0
8
0
0
15
0
% E
% Phe:
50
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
8
0
36
0
0
8
0
8
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% H
% Ile:
0
15
0
8
8
0
0
0
8
0
0
0
50
0
0
% I
% Lys:
0
8
0
15
15
0
0
0
58
8
29
0
8
0
15
% K
% Leu:
0
15
0
15
43
0
8
0
0
0
0
15
8
50
8
% L
% Met:
0
0
0
8
8
0
0
0
0
0
8
0
15
15
0
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
8
58
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
8
0
0
8
0
0
8
0
0
0
0
% R
% Ser:
8
0
0
8
0
8
0
0
0
0
0
8
0
8
15
% S
% Thr:
8
0
0
0
8
79
8
0
15
79
15
0
0
0
0
% T
% Val:
0
22
8
0
0
0
0
8
15
8
8
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
72
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _