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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6B
All Species:
13.94
Human Site:
Y645
Identified Species:
23.59
UniProt:
P35913
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35913
NP_000274.2
854
98336
Y645
S
E
E
T
L
N
I
Y
Q
N
L
N
R
R
Q
Chimpanzee
Pan troglodytes
XP_518030
860
99527
F647
R
D
E
S
L
N
I
F
Q
N
L
N
R
R
Q
Rhesus Macaque
Macaca mulatta
XP_001094732
854
97937
Y644
S
E
E
T
L
N
I
Y
Q
N
L
N
R
R
Q
Dog
Lupus familis
XP_543934
846
97567
F635
Q
D
E
S
L
N
I
F
Q
N
L
N
K
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
P23440
856
98483
Y645
A
E
E
S
L
N
I
Y
Q
N
L
N
R
R
Q
Rat
Rattus norvegicus
Q8VID6
935
104553
I752
L
Q
S
E
G
H
N
I
F
A
N
L
S
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512709
856
98818
Y645
A
D
E
T
L
N
I
Y
Q
N
L
N
R
R
Q
Chicken
Gallus gallus
P52731
862
99990
F650
Q
D
E
S
L
N
I
F
Q
N
L
N
K
R
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685002
854
98605
F646
G
E
E
S
L
N
I
F
Q
N
L
N
R
R
Q
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
I706
L
Q
S
E
G
H
N
I
F
C
N
L
S
S
T
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
F819
N
S
E
G
N
N
I
F
Q
A
L
S
P
E
D
Honey Bee
Apis mellifera
XP_394107
1016
115998
F754
N
S
D
S
N
N
I
F
Q
S
L
S
M
E
D
Nematode Worm
Caenorhab. elegans
P91119
710
81117
S549
L
A
S
I
Y
S
T
S
V
M
E
R
H
H
F
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
F706
N
S
E
G
N
N
I
F
E
F
M
S
P
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.4
93.9
63.8
N.A.
92.5
24.9
N.A.
86.2
64.5
N.A.
76.1
24.2
23.7
25.6
23.8
32.9
Protein Similarity:
100
82.3
96.7
79.1
N.A.
96.2
44.1
N.A.
92.6
78.8
N.A.
85.1
43.7
41.2
44.6
42.3
53.2
P-Site Identity:
100
73.3
100
66.6
N.A.
86.6
0
N.A.
86.6
66.6
N.A.
80
0
33.3
26.6
0
20
P-Site Similarity:
100
93.3
100
93.3
N.A.
100
20
N.A.
100
93.3
N.A.
93.3
13.3
53.3
66.6
6.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
0
0
0
0
0
0
15
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
29
8
0
0
0
0
0
0
0
0
0
0
8
22
% D
% Glu:
0
29
72
15
0
0
0
0
8
0
8
0
0
15
0
% E
% Phe:
0
0
0
0
0
0
0
50
15
8
0
0
0
0
8
% F
% Gly:
8
0
0
15
15
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
15
0
0
0
0
0
0
8
8
0
% H
% Ile:
0
0
0
8
0
0
79
15
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
8
% K
% Leu:
22
0
0
0
58
0
0
0
0
0
72
15
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
0
% M
% Asn:
22
0
0
0
22
79
15
0
0
58
15
58
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% P
% Gln:
15
15
0
0
0
0
0
0
72
0
0
0
0
0
58
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
8
43
58
0
% R
% Ser:
15
22
22
43
0
8
0
8
0
8
0
22
15
15
0
% S
% Thr:
0
0
0
22
0
0
8
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
29
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _