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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCL
All Species:
26.67
Human Site:
S181
Identified Species:
48.89
UniProt:
P35914
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35914
NP_000182.2
325
34360
S181
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
Chimpanzee
Pan troglodytes
XP_001166273
325
34328
S181
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
Rhesus Macaque
Macaca mulatta
XP_001104722
331
34676
S187
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
Dog
Lupus familis
XP_535360
325
34200
S181
C
P
Y
E
G
K
I
S
P
A
K
V
V
E
V
Cat
Felis silvestris
Mouse
Mus musculus
P38060
325
34142
S181
C
P
Y
E
G
K
V
S
P
A
K
V
A
E
V
Rat
Rattus norvegicus
P97519
325
34173
S181
C
P
Y
E
G
K
V
S
P
A
K
V
A
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P35915
298
31418
S154
C
P
Y
E
G
N
I
S
A
A
K
V
A
E
V
Frog
Xenopus laevis
NP_001085152
328
34788
A184
C
P
Y
E
G
K
V
A
P
S
K
V
A
E
V
Zebra Danio
Brachydanio rerio
A8WG57
335
35873
K191
C
P
Y
E
G
Q
V
K
P
S
Q
V
T
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609089
323
34155
A174
C
P
Y
E
G
A
V
A
P
S
A
V
V
K
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001196745
313
33056
Q169
C
P
Y
E
G
A
V
Q
P
E
A
V
A
K
V
Poplar Tree
Populus trichocarpa
XP_002308880
293
30640
S155
V
E
G
M
V
S
P
S
K
V
A
Y
V
A
K
Maize
Zea mays
NP_001132253
434
44858
P283
C
P
V
D
G
P
V
P
P
S
N
V
A
Y
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
89.7
87
N.A.
87
88.9
N.A.
N.A.
72.9
71.3
64.7
N.A.
59.3
N.A.
N.A.
63.6
Protein Similarity:
100
100
91.2
90.7
N.A.
93.8
95.6
N.A.
N.A.
83
82.6
77.9
N.A.
75
N.A.
N.A.
78.4
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
53.3
N.A.
53.3
N.A.
N.A.
60
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
86.6
100
86.6
N.A.
80
N.A.
N.A.
73.3
Percent
Protein Identity:
57.8
48.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
70.7
60.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
46.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
6.6
66.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
16
0
16
8
54
24
0
70
8
0
% A
% Cys:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
85
0
0
0
0
0
8
0
0
0
62
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
93
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
54
0
8
8
0
62
0
0
24
8
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
93
0
0
0
8
8
8
85
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
8
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
62
0
31
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% T
% Val:
8
0
8
0
8
0
54
0
0
8
0
93
24
0
93
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
85
0
0
0
0
0
0
0
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _