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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCL
All Species:
25.15
Human Site:
S315
Identified Species:
46.11
UniProt:
P35914
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35914
NP_000182.2
325
34360
S315
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
Chimpanzee
Pan troglodytes
XP_001166273
325
34328
S315
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
Rhesus Macaque
Macaca mulatta
XP_001104722
331
34676
S321
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
Dog
Lupus familis
XP_535360
325
34200
S315
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P38060
325
34142
S315
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
Rat
Rattus norvegicus
P97519
325
34173
S315
Q
A
L
N
R
K
T
S
S
K
V
A
Q
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P35915
298
31418
N288
N
A
L
N
R
R
T
N
S
K
V
S
Q
A
A
Frog
Xenopus laevis
NP_001085152
328
34788
H318
K
A
L
G
K
K
S
H
S
K
V
S
Q
A
I
Zebra Danio
Brachydanio rerio
A8WG57
335
35873
N325
K
A
L
N
R
K
T
N
S
K
V
S
Q
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609089
323
34155
E308
T
E
L
G
R
T
S
E
S
K
V
N
R
A
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001196745
313
33056
T303
R
E
L
G
R
Q
N
T
S
K
V
G
N
A
M
Poplar Tree
Populus trichocarpa
XP_002308880
293
30640
K280
L
A
G
N
F
I
S
K
H
L
G
H
S
S
G
Maize
Zea mays
NP_001132253
434
44858
G417
R
H
L
G
R
Q
S
G
S
K
A
A
T
A
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
89.7
87
N.A.
87
88.9
N.A.
N.A.
72.9
71.3
64.7
N.A.
59.3
N.A.
N.A.
63.6
Protein Similarity:
100
100
91.2
90.7
N.A.
93.8
95.6
N.A.
N.A.
83
82.6
77.9
N.A.
75
N.A.
N.A.
78.4
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
66.6
53.3
80
N.A.
40
N.A.
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
86.6
80
100
N.A.
53.3
N.A.
N.A.
60
Percent
Protein Identity:
57.8
48.1
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
70.7
60.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
60
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
77
0
0
0
0
0
0
0
0
8
54
0
93
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
16
0
0
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
31
0
0
0
8
0
0
8
8
0
0
8
% G
% His:
0
8
0
0
0
0
0
8
8
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% I
% Lys:
16
0
0
0
8
62
0
8
0
93
0
0
0
0
0
% K
% Leu:
8
0
93
0
0
0
0
0
0
8
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
70
0
0
8
16
0
0
0
8
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
47
0
0
0
0
16
0
0
0
0
0
0
70
0
0
% Q
% Arg:
16
0
0
0
85
8
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
31
47
93
0
0
24
8
8
0
% S
% Thr:
8
0
0
0
0
8
62
8
0
0
0
0
8
0
47
% T
% Val:
0
0
0
0
0
0
0
0
0
0
85
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _