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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCL All Species: 21.52
Human Site: T23 Identified Species: 39.44
UniProt: P35914 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35914 NP_000182.2 325 34360 T23 A S L R A V S T S S M G T L P
Chimpanzee Pan troglodytes XP_001166273 325 34328 T23 A S L R A V S T S S M G T L P
Rhesus Macaque Macaca mulatta XP_001104722 331 34676 A23 A S L R A V S A P S R R G G G
Dog Lupus familis XP_535360 325 34200 T23 A S L R A V S T F S L G T F P
Cat Felis silvestris
Mouse Mus musculus P38060 325 34142 T23 T S L R A V S T S S M G T L P
Rat Rattus norvegicus P97519 325 34173 T23 A S L R A A S T S S M G T L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P35915 298 31418 R14 K V V E V G P R D G L Q N E K
Frog Xenopus laevis NP_001085152 328 34788 S26 A I L R Q I G S L P I Q S F P
Zebra Danio Brachydanio rerio A8WG57 335 35873 C33 R L L W E E K C S E L P K L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609089 323 34155 V19 L T A K R T A V T S A A N Q V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196745 313 33056 P18 A G R D A Q I P R S V K I V E
Poplar Tree Populus trichocarpa XP_002308880 293 30640 G15 V E V G P R D G L Q N E K D I
Maize Zea mays NP_001132253 434 44858 S115 H I Y R Y F S S S H Q G S I W
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 89.7 87 N.A. 87 88.9 N.A. N.A. 72.9 71.3 64.7 N.A. 59.3 N.A. N.A. 63.6
Protein Similarity: 100 100 91.2 90.7 N.A. 93.8 95.6 N.A. N.A. 83 82.6 77.9 N.A. 75 N.A. N.A. 78.4
P-Site Identity: 100 100 53.3 80 N.A. 93.3 93.3 N.A. N.A. 0 26.6 26.6 N.A. 6.6 N.A. N.A. 20
P-Site Similarity: 100 100 53.3 86.6 N.A. 93.3 93.3 N.A. N.A. 13.3 53.3 33.3 N.A. 33.3 N.A. N.A. 33.3
Percent
Protein Identity: 57.8 48.1 N.A. N.A. N.A. N.A.
Protein Similarity: 70.7 60.1 N.A. N.A. N.A. N.A.
P-Site Identity: 0 26.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 6.6 46.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 54 0 8 0 54 8 8 8 0 0 8 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 8 0 8 0 0 0 0 8 0 % D
% Glu: 0 8 0 8 8 8 0 0 0 8 0 8 0 8 8 % E
% Phe: 0 0 0 0 0 8 0 0 8 0 0 0 0 16 0 % F
% Gly: 0 8 0 8 0 8 8 8 0 8 0 47 8 8 8 % G
% His: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 16 0 0 0 8 8 0 0 0 8 0 8 8 8 % I
% Lys: 8 0 0 8 0 0 8 0 0 0 0 8 16 0 8 % K
% Leu: 8 8 62 0 0 0 0 0 16 0 24 0 0 39 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 31 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 16 0 0 % N
% Pro: 0 0 0 0 8 0 8 8 8 8 0 8 0 0 54 % P
% Gln: 0 0 0 0 8 8 0 0 0 8 8 16 0 8 0 % Q
% Arg: 8 0 8 62 8 8 0 8 8 0 8 8 0 0 0 % R
% Ser: 0 47 0 0 0 0 54 16 47 62 0 0 16 0 0 % S
% Thr: 8 8 0 0 0 8 0 39 8 0 0 0 39 0 0 % T
% Val: 8 8 16 0 8 39 0 8 0 0 8 0 0 8 8 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _