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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC2 All Species: 54.55
Human Site: S380 Identified Species: 85.71
UniProt: P35998 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35998 NP_002794.1 433 48634 S380 L A R L C P N S T G A E I R S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533103 906 98310 S853 L A R L C P N S T G A E I R S
Cat Felis silvestris
Mouse Mus musculus P46471 433 48629 S380 L A R L C P N S T G A E I R S
Rat Rattus norvegicus Q63347 433 48556 S380 L A R L C P N S T G A E I R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507929 476 53606 S423 L A R L C P N S T G A E I R S
Chicken Gallus gallus NP_001006225 433 48643 S380 L A R L C P N S T G A E I R S
Frog Xenopus laevis P46472 433 48645 S380 L A R L C P N S T G A E I R S
Zebra Danio Brachydanio rerio NP_957260 433 48685 S380 L A R L C P N S T G A E I R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O18413 405 45839 A353 I A E L M P G A S G A E V K G
Honey Bee Apis mellifera XP_623743 434 48438 S381 L A R L C P N S T G A E I R S
Nematode Worm Caenorhab. elegans Q18787 435 48592 S382 L A R L C P N S T G A E I R S
Sea Urchin Strong. purpuratus XP_001190601 414 46080 C361 L A R L C P N C T G A E I R S
Poplar Tree Populus trichocarpa XP_002308501 429 47955 S376 L A R L C P N S T G A D I R S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SSB5 426 47785 S373 L A R L C P N S T G A D I R S
Baker's Yeast Sacchar. cerevisiae P33299 467 51964 S414 I S R L C P N S T G A E L R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 47.7 N.A. 99.7 99.7 N.A. 88.4 99.5 99 98.8 N.A. 44.3 91.9 85.5 86.3
Protein Similarity: 100 N.A. N.A. 47.7 N.A. 100 99.7 N.A. 89.9 100 100 99.5 N.A. 62.5 97 93.5 91.9
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 40 100 100 93.3
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 73.3 100 100 93.3
Percent
Protein Identity: 78.9 N.A. N.A. 79.2 70 N.A.
Protein Similarity: 87.5 N.A. N.A. 88.2 81.3 N.A.
P-Site Identity: 93.3 N.A. N.A. 93.3 80 N.A.
P-Site Similarity: 100 N.A. N.A. 100 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 94 0 0 0 0 0 7 0 0 100 0 0 0 0 % A
% Cys: 0 0 0 0 94 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 % D
% Glu: 0 0 7 0 0 0 0 0 0 0 0 87 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 7 0 0 100 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 14 0 0 0 0 0 0 0 0 0 0 0 87 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % K
% Leu: 87 0 0 100 0 0 0 0 0 0 0 0 7 0 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 94 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 94 0 0 0 0 0 0 0 0 0 0 94 0 % R
% Ser: 0 7 0 0 0 0 0 87 7 0 0 0 0 0 94 % S
% Thr: 0 0 0 0 0 0 0 0 94 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _