Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FLT3 All Species: 13.64
Human Site: S740 Identified Species: 30
UniProt: P36888 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.5
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P36888 NP_004110.2 993 112903 S740 P N S S M P G S R E V Q I H P
Chimpanzee Pan troglodytes XP_509601 993 112798 S740 P N S S M P G S R E V Q I H P
Rhesus Macaque Macaca mulatta XP_001117913 993 112706 S740 P N S S M P G S R D V Q I H P
Dog Lupus familis XP_546306 967 107148 D709 E K K Y V R R D S G F S S Q G
Cat Felis silvestris
Mouse Mus musculus Q00342 992 112621 S741 S N S S M P G S R E V Q L H P
Rat Rattus norvegicus Q00495 978 109246 D710 E K K Y V R R D S G F S S Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519582 987 111585 S740 Y P R L H L H S N T S T H D F
Chicken Gallus gallus Q08156 960 107293 E705 P T A D A V N E Y M D M K P G
Frog Xenopus laevis Q91909 954 106841 E707 M G C E G M S E Y I D M K P A
Zebra Danio Brachydanio rerio Q8JFR5 976 109261 M710 S R N G Y M T M K P S V L G I
Tiger Blowfish Takifugu rubipres P79750 975 110895 D715 Q K W Y I R S D S G I S S T S
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 96.4 30.3 N.A. 83.9 29.6 N.A. 66.8 31.5 30.7 33.8 30.6 N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 98.4 48.5 N.A. 89.7 47.6 N.A. 80.5 48.4 46.6 49.7 47.4 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 0 N.A. 86.6 0 N.A. 6.6 6.6 0 0 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 93.3 6.6 N.A. 6.6 13.3 0 20 13.3 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 10 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 0 28 0 10 19 0 0 10 0 % D
% Glu: 19 0 0 10 0 0 0 19 0 28 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 10 % F
% Gly: 0 10 0 10 10 0 37 0 0 28 0 0 0 10 28 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 0 10 37 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 10 10 0 28 0 10 % I
% Lys: 0 28 19 0 0 0 0 0 10 0 0 0 19 0 0 % K
% Leu: 0 0 0 10 0 10 0 0 0 0 0 0 19 0 0 % L
% Met: 10 0 0 0 37 19 0 10 0 10 0 19 0 0 0 % M
% Asn: 0 37 10 0 0 0 10 0 10 0 0 0 0 0 0 % N
% Pro: 37 10 0 0 0 37 0 0 0 10 0 0 0 19 37 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 37 0 19 0 % Q
% Arg: 0 10 10 0 0 28 19 0 37 0 0 0 0 0 0 % R
% Ser: 19 0 37 37 0 0 19 46 28 0 19 28 28 0 10 % S
% Thr: 0 10 0 0 0 0 10 0 0 10 0 10 0 10 0 % T
% Val: 0 0 0 0 19 10 0 0 0 0 37 10 0 0 0 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 28 10 0 0 0 19 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _