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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FLT3
All Species:
11.82
Human Site:
S753
Identified Species:
26
UniProt:
P36888
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36888
NP_004110.2
993
112903
S753
H
P
D
S
D
Q
I
S
G
L
H
G
N
S
F
Chimpanzee
Pan troglodytes
XP_509601
993
112798
S753
H
P
D
S
D
Q
I
S
G
L
H
G
N
S
F
Rhesus Macaque
Macaca mulatta
XP_001117913
993
112706
S753
H
P
H
S
D
P
I
S
G
L
H
G
N
S
F
Dog
Lupus familis
XP_546306
967
107148
E722
Q
G
V
D
T
Y
V
E
M
R
P
V
S
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q00342
992
112621
S754
H
P
P
L
D
Q
L
S
G
F
N
G
N
S
I
Rat
Rattus norvegicus
Q00495
978
109246
E723
Q
G
V
D
T
Y
V
E
M
R
P
V
S
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519582
987
111585
N753
D
F
E
D
V
P
M
N
G
N
F
D
L
I
D
Chicken
Gallus gallus
Q08156
960
107293
P718
P
G
V
S
Y
A
V
P
P
K
A
D
K
K
R
Frog
Xenopus laevis
Q91909
954
106841
P720
P
A
V
S
Y
V
V
P
T
K
T
D
K
R
R
Zebra Danio
Brachydanio rerio
Q8JFR5
976
109261
R723
G
I
L
S
S
E
N
R
R
S
L
N
K
G
D
Tiger Blowfish
Takifugu rubipres
P79750
975
110895
E728
T
S
S
S
T
Y
L
E
M
R
P
S
Q
Q
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
96.4
30.3
N.A.
83.9
29.6
N.A.
66.8
31.5
30.7
33.8
30.6
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.4
48.5
N.A.
89.7
47.6
N.A.
80.5
48.4
46.6
49.7
47.4
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
0
N.A.
60
0
N.A.
6.6
6.6
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
20
N.A.
73.3
20
N.A.
26.6
13.3
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
19
28
37
0
0
0
0
0
0
28
0
0
19
% D
% Glu:
0
0
10
0
0
10
0
28
0
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
10
10
0
0
0
28
% F
% Gly:
10
28
0
0
0
0
0
0
46
0
0
37
0
10
0
% G
% His:
37
0
10
0
0
0
0
0
0
0
28
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
28
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
19
0
0
28
10
0
% K
% Leu:
0
0
10
10
0
0
19
0
0
28
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
10
0
28
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
10
0
10
10
10
37
0
0
% N
% Pro:
19
37
10
0
0
19
0
19
10
0
28
0
0
0
0
% P
% Gln:
19
0
0
0
0
28
0
0
0
0
0
0
10
10
0
% Q
% Arg:
0
0
0
0
0
0
0
10
10
28
0
0
0
10
19
% R
% Ser:
0
10
10
64
10
0
0
37
0
10
0
10
19
37
28
% S
% Thr:
10
0
0
0
28
0
0
0
10
0
10
0
0
19
0
% T
% Val:
0
0
37
0
10
10
37
0
0
0
0
19
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
19
28
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _