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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVRL1
All Species:
16.06
Human Site:
S495
Identified Species:
29.44
UniProt:
P37023
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37023
NP_000011.2
503
56124
S495
T
L
Q
K
I
S
N
S
P
E
K
P
K
V
I
Chimpanzee
Pan troglodytes
XP_001145379
494
55044
E486
W
A
Q
E
L
V
S
E
A
S
A
S
S
H
R
Rhesus Macaque
Macaca mulatta
XP_001090993
503
56074
S495
T
L
Q
K
I
S
N
S
P
E
K
P
K
V
I
Dog
Lupus familis
XP_534796
504
56421
G496
T
L
Q
K
L
S
N
G
L
E
K
S
K
V
I
Cat
Felis silvestris
Mouse
Mus musculus
Q61288
502
56614
N494
T
L
Q
K
L
S
H
N
P
E
K
P
K
V
I
Rat
Rattus norvegicus
P80203
504
56685
N496
T
L
Q
K
L
S
Q
N
P
E
K
P
K
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509625
512
57592
S504
T
L
T
K
I
D
N
S
L
D
K
L
K
A
D
Chicken
Gallus gallus
Q90ZK6
504
56206
S496
T
L
T
K
I
D
N
S
L
D
K
L
K
A
D
Frog
Xenopus laevis
P27041
511
57917
S483
R
I
S
Q
I
R
K
S
V
N
G
T
T
S
D
Zebra Danio
Brachydanio rerio
NP_571420
506
56709
S498
T
L
D
K
I
H
S
S
L
E
K
G
K
T
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523652
570
64210
A557
T
I
H
K
L
A
S
A
D
E
K
I
R
L
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09488
636
72217
N608
E
M
A
E
L
I
K
N
P
D
R
Q
N
Q
S
Sea Urchin
Strong. purpuratus
XP_794984
512
58526
T497
T
L
M
K
I
S
E
T
C
P
K
L
T
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.4
98.6
93
N.A.
88.4
89.4
N.A.
58.7
61.3
30.5
59.2
N.A.
47.3
N.A.
31.4
49.6
Protein Similarity:
100
93.2
99.1
95.6
N.A.
93
93.2
N.A.
71.8
74
46.3
70.9
N.A.
61.9
N.A.
47.1
64.8
P-Site Identity:
100
6.6
100
73.3
N.A.
80
80
N.A.
53.3
53.3
13.3
53.3
N.A.
26.6
N.A.
6.6
40
P-Site Similarity:
100
26.6
100
80
N.A.
100
93.3
N.A.
60
60
26.6
60
N.A.
73.3
N.A.
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
0
8
8
0
8
0
0
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
16
0
0
8
24
0
0
0
8
39
% D
% Glu:
8
0
0
16
0
0
8
8
0
54
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
8
8
0
0
0
% G
% His:
0
0
8
0
0
8
8
0
0
0
0
0
0
8
0
% H
% Ile:
0
16
0
0
54
8
0
0
0
0
0
8
0
0
39
% I
% Lys:
0
0
0
77
0
0
16
0
0
0
77
0
62
0
0
% K
% Leu:
0
70
0
0
47
0
0
0
31
0
0
24
0
8
0
% L
% Met:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
39
24
0
8
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
39
8
0
31
0
0
8
% P
% Gln:
0
0
47
8
0
0
8
0
0
0
0
8
0
8
0
% Q
% Arg:
8
0
0
0
0
8
0
0
0
0
8
0
8
0
8
% R
% Ser:
0
0
8
0
0
47
24
47
0
8
0
16
8
8
8
% S
% Thr:
77
0
16
0
0
0
0
8
0
0
0
8
16
8
0
% T
% Val:
0
0
0
0
0
8
0
0
8
0
0
0
0
39
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _