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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVRL1
All Species:
38.79
Human Site:
Y279
Identified Species:
71.11
UniProt:
P37023
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37023
NP_000011.2
503
56124
Y279
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
Chimpanzee
Pan troglodytes
XP_001145379
494
55044
M264
L
G
F
I
A
S
D
M
T
S
R
N
S
S
T
Rhesus Macaque
Macaca mulatta
XP_001090993
503
56074
Y279
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
Dog
Lupus familis
XP_534796
504
56421
Y280
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61288
502
56614
Y278
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
Rat
Rattus norvegicus
P80203
504
56685
Y280
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509625
512
57592
Y288
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
Chicken
Gallus gallus
Q90ZK6
504
56206
Y280
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
Frog
Xenopus laevis
P27041
511
57917
F266
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
Zebra Danio
Brachydanio rerio
NP_571420
506
56709
Y282
Q
L
W
L
I
T
H
Y
H
E
N
G
S
L
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523652
570
64210
Y341
Q
L
W
L
M
T
H
Y
Y
P
L
G
S
L
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09488
636
72217
D342
T
K
M
L
L
I
T
D
Y
H
E
L
G
S
L
Sea Urchin
Strong. purpuratus
XP_794984
512
58526
Y281
Q
L
W
L
I
M
E
Y
H
E
R
G
S
L
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.4
98.6
93
N.A.
88.4
89.4
N.A.
58.7
61.3
30.5
59.2
N.A.
47.3
N.A.
31.4
49.6
Protein Similarity:
100
93.2
99.1
95.6
N.A.
93
93.2
N.A.
71.8
74
46.3
70.9
N.A.
61.9
N.A.
47.1
64.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
93.3
93.3
60
93.3
N.A.
66.6
N.A.
6.6
80
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
93.3
93.3
80
100
N.A.
86.6
N.A.
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
8
0
8
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
8
0
0
70
8
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
85
8
0
0
% G
% His:
0
0
0
0
0
0
70
0
77
8
39
0
0
0
0
% H
% Ile:
0
0
0
8
77
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
8
85
0
93
8
0
0
0
0
0
8
8
0
85
8
% L
% Met:
0
0
8
0
8
8
0
8
0
0
16
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
77
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
0
0
8
0
0
93
16
0
% S
% Thr:
8
0
0
0
0
77
8
0
8
0
0
0
0
0
16
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
85
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
77
16
0
0
0
0
0
70
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _