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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVRL1
All Species:
41.21
Human Site:
Y421
Identified Species:
75.56
UniProt:
P37023
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37023
NP_000011.2
503
56124
Y421
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
Chimpanzee
Pan troglodytes
XP_001145379
494
55044
T412
L
W
E
I
A
R
R
T
I
V
N
G
I
V
E
Rhesus Macaque
Macaca mulatta
XP_001090993
503
56074
Y421
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
Dog
Lupus familis
XP_534796
504
56421
Y422
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61288
502
56614
Y420
I
N
G
I
V
E
D
Y
R
P
P
F
Y
D
M
Rat
Rattus norvegicus
P80203
504
56685
Y422
I
N
G
I
V
E
D
Y
R
P
P
F
Y
D
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509625
512
57592
Y430
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
Chicken
Gallus gallus
Q90ZK6
504
56206
Y422
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
L
Frog
Xenopus laevis
P27041
511
57917
Y409
A
D
G
P
V
D
E
Y
L
L
P
F
E
E
E
Zebra Danio
Brachydanio rerio
NP_571420
506
56709
Y424
S
N
G
I
V
E
E
Y
K
P
P
F
Y
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523652
570
64210
Y483
S
C
G
I
A
E
E
Y
K
V
P
F
Y
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09488
636
72217
H534
T
S
L
K
A
K
Q
H
V
P
P
F
D
G
I
Sea Urchin
Strong. purpuratus
XP_794984
512
58526
Y423
V
G
G
M
V
A
D
Y
K
P
P
F
F
E
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.4
98.6
93
N.A.
88.4
89.4
N.A.
58.7
61.3
30.5
59.2
N.A.
47.3
N.A.
31.4
49.6
Protein Similarity:
100
93.2
99.1
95.6
N.A.
93
93.2
N.A.
71.8
74
46.3
70.9
N.A.
61.9
N.A.
47.1
64.8
P-Site Identity:
100
6.6
100
100
N.A.
86.6
86.6
N.A.
86.6
80
33.3
73.3
N.A.
60
N.A.
20
53.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
93.3
60
93.3
N.A.
73.3
N.A.
46.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
24
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
8
62
0
0
0
0
0
8
70
0
% D
% Glu:
0
0
8
0
0
70
24
0
0
0
0
0
8
16
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
93
8
0
0
% F
% Gly:
0
8
85
0
0
0
0
0
0
0
0
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
16
0
0
77
0
0
0
0
8
0
0
0
8
0
8
% I
% Lys:
0
0
0
8
0
8
0
0
39
0
0
0
0
0
0
% K
% Leu:
8
0
8
0
0
0
0
0
8
8
0
0
0
0
16
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
16
% M
% Asn:
0
62
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
77
93
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
8
0
39
0
0
0
0
0
0
% R
% Ser:
31
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
31
0
0
0
77
0
0
0
8
16
0
0
0
8
39
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
85
0
0
0
0
70
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _