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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVRL1
All Species:
35.76
Human Site:
Y426
Identified Species:
65.56
UniProt:
P37023
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37023
NP_000011.2
503
56124
Y426
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
Chimpanzee
Pan troglodytes
XP_001145379
494
55044
I417
R
R
T
I
V
N
G
I
V
E
D
Y
R
P
P
Rhesus Macaque
Macaca mulatta
XP_001090993
503
56074
Y426
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
Dog
Lupus familis
XP_534796
504
56421
Y427
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61288
502
56614
Y425
E
D
Y
R
P
P
F
Y
D
M
V
P
N
D
P
Rat
Rattus norvegicus
P80203
504
56685
Y427
E
D
Y
R
P
P
F
Y
D
M
V
P
N
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509625
512
57592
Y435
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
Chicken
Gallus gallus
Q90ZK6
504
56206
Y427
E
D
Y
K
P
P
F
Y
D
L
V
P
N
D
P
Frog
Xenopus laevis
P27041
511
57917
E414
D
E
Y
L
L
P
F
E
E
E
I
G
Q
H
P
Zebra Danio
Brachydanio rerio
NP_571420
506
56709
Y429
E
E
Y
K
P
P
F
Y
D
L
V
P
N
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523652
570
64210
Y488
E
E
Y
K
V
P
F
Y
D
V
V
P
M
D
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09488
636
72217
D539
K
Q
H
V
P
P
F
D
G
I
V
H
N
D
P
Sea Urchin
Strong. purpuratus
XP_794984
512
58526
F428
A
D
Y
K
P
P
F
F
E
Y
V
P
S
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.4
98.6
93
N.A.
88.4
89.4
N.A.
58.7
61.3
30.5
59.2
N.A.
47.3
N.A.
31.4
49.6
Protein Similarity:
100
93.2
99.1
95.6
N.A.
93
93.2
N.A.
71.8
74
46.3
70.9
N.A.
61.9
N.A.
47.1
64.8
P-Site Identity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
93.3
86.6
26.6
80
N.A.
73.3
N.A.
46.6
60
P-Site Similarity:
100
6.6
100
100
N.A.
100
100
N.A.
100
100
53.3
100
N.A.
86.6
N.A.
66.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
62
0
0
0
0
0
8
70
0
8
0
0
85
0
% D
% Glu:
70
24
0
0
0
0
0
8
16
16
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
93
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
8
0
0
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
8
0
8
0
% H
% Ile:
0
0
0
8
0
0
0
8
0
8
8
0
0
0
0
% I
% Lys:
8
0
0
39
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
8
0
0
0
0
16
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
16
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
70
0
0
% N
% Pro:
0
0
0
0
77
93
0
0
0
0
0
77
0
8
100
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
8
0
39
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
16
0
0
0
8
39
85
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
85
0
0
0
0
70
0
8
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _