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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B3
All Species:
39.09
Human Site:
S196
Identified Species:
78.18
UniProt:
P37058
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37058
NP_000188.1
310
34516
S196
L
F
P
W
P
L
Y
S
M
Y
S
A
S
K
A
Chimpanzee
Pan troglodytes
XP_001151508
310
34564
S196
L
F
P
W
P
L
Y
S
M
Y
S
A
S
K
A
Rhesus Macaque
Macaca mulatta
XP_001105829
310
34699
S196
L
F
P
W
P
L
Y
S
M
Y
S
A
S
K
A
Dog
Lupus familis
XP_848540
520
56897
S196
L
F
P
W
P
L
Y
S
M
Y
S
A
S
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P70385
305
34252
S192
L
R
P
W
P
L
Y
S
L
Y
S
A
S
K
A
Rat
Rattus norvegicus
O54939
306
34205
S192
V
R
P
W
P
L
Y
S
L
Y
S
A
S
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJG8
331
37589
T216
C
Q
P
T
P
M
L
T
T
Y
G
A
S
K
A
Frog
Xenopus laevis
Q8AVY8
318
34842
T205
M
Y
P
V
P
L
L
T
V
Y
S
A
T
K
A
Zebra Danio
Brachydanio rerio
Q6P3L6
319
35532
T206
M
F
P
V
P
L
L
T
I
Y
S
S
T
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572420
321
35098
S204
V
I
P
N
P
L
L
S
V
Y
S
S
T
K
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17703
314
34587
S200
L
A
T
M
A
E
W
S
V
Y
S
A
T
K
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
A207
V
M
P
T
P
Y
L
A
T
Y
S
G
S
K
A
Conservation
Percent
Protein Identity:
100
98.7
95.4
48.4
N.A.
71.9
73.5
N.A.
N.A.
34.1
39.3
41
N.A.
36.7
N.A.
35.9
N.A.
Protein Similarity:
100
99.6
98.3
53.6
N.A.
80.6
83.5
N.A.
N.A.
53.7
57.8
57.9
N.A.
55.7
N.A.
50
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
80
N.A.
N.A.
46.6
53.3
53.3
N.A.
53.3
N.A.
40
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
60
86.6
86.6
N.A.
80
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
32.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
51.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
0
9
0
0
0
75
0
0
92
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
42
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
100
9
% K
% Leu:
50
0
0
0
0
75
42
0
17
0
0
0
0
0
0
% L
% Met:
17
9
0
9
0
9
0
0
34
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
92
0
92
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
67
0
0
92
17
67
0
0
% S
% Thr:
0
0
9
17
0
0
0
25
17
0
0
0
34
0
0
% T
% Val:
25
0
0
17
0
0
0
0
25
0
0
0
0
0
0
% V
% Trp:
0
0
0
50
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
9
50
0
0
100
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _