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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
9.7
Human Site:
Y27
Identified Species:
19.39
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
Y27
C
G
T
V
F
C
K
Y
K
K
S
S
G
Q
L
Chimpanzee
Pan troglodytes
XP_511130
387
42727
Y27
C
G
T
V
F
C
K
Y
K
K
S
S
G
Q
L
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
Y27
C
G
T
V
F
C
K
Y
K
K
S
S
G
Q
L
Dog
Lupus familis
XP_546810
382
41989
P30
L
G
N
L
R
K
I
P
G
Q
M
R
R
K
V
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
C27
G
G
T
L
L
C
G
C
R
S
G
R
Q
L
R
Rat
Rattus norvegicus
Q62730
381
41949
A27
G
G
M
L
L
C
K
A
W
S
S
G
Q
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
T27
L
S
R
R
L
G
E
T
L
V
I
I
I
R
R
Chicken
Gallus gallus
Q5ZJZ5
339
38218
P9
L
A
T
K
L
S
R
P
L
L
N
L
P
V
K
Frog
Xenopus laevis
NP_001086062
388
43271
N29
L
G
F
L
R
F
S
N
S
D
V
V
L
T
P
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
A29
S
V
V
V
W
L
G
A
T
L
L
V
E
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
D27
L
L
Q
L
L
R
S
D
L
R
L
G
R
P
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
20
26.6
N.A.
0
6.6
6.6
13.3
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
33.3
33.3
N.A.
13.3
20
13.3
26.6
N.A.
0
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
17
0
0
0
0
0
0
0
% A
% Cys:
25
0
0
0
0
42
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
9
0
25
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
17
59
0
0
0
9
17
0
9
0
9
17
25
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
9
9
9
0
0
% I
% Lys:
0
0
0
9
0
9
34
0
25
25
0
0
0
9
9
% K
% Leu:
42
9
0
42
42
9
0
0
25
17
17
9
9
17
42
% L
% Met:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
9
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
17
0
0
0
0
9
9
9
% P
% Gln:
0
0
9
0
0
0
0
0
0
9
0
0
17
25
0
% Q
% Arg:
0
0
9
9
17
9
9
0
9
9
0
17
17
17
25
% R
% Ser:
9
9
0
0
0
9
17
0
9
17
34
25
0
0
0
% S
% Thr:
0
0
42
0
0
0
0
9
9
0
0
0
0
9
0
% T
% Val:
0
9
9
34
0
0
0
0
0
9
9
17
0
9
9
% V
% Trp:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
25
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _