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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
32.12
Human Site:
Y299
Identified Species:
64.24
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
Y299
Q
E
D
Y
G
Q
D
Y
I
L
A
Q
R
N
F
Chimpanzee
Pan troglodytes
XP_511130
387
42727
Y299
Q
E
D
Y
G
Q
D
Y
I
L
A
Q
R
N
F
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
Y298
Q
E
D
Y
G
Q
D
Y
I
L
S
Q
K
N
F
Dog
Lupus familis
XP_546810
382
41989
Y300
E
E
D
Y
G
K
D
Y
I
L
Q
Q
R
N
Y
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
Y300
Q
E
N
Y
G
Q
D
Y
V
H
T
Q
K
L
I
Rat
Rattus norvegicus
Q62730
381
41949
Y300
Q
E
N
Y
G
Q
E
Y
V
H
T
Q
K
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
Y291
K
E
D
Y
G
I
G
Y
I
Q
A
L
K
N
L
Chicken
Gallus gallus
Q5ZJZ5
339
38218
D258
A
I
A
D
K
M
W
D
E
L
P
E
I
V
R
Frog
Xenopus laevis
NP_001086062
388
43271
Y303
L
Q
E
Y
G
E
E
Y
I
T
E
T
Q
N
K
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
Y288
L
E
E
Y
G
E
E
Y
L
L
E
T
K
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
S244
G
Y
I
R
T
Q
L
S
L
N
A
L
T
G
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
Y299
L
Q
A
Y
G
E
D
Y
I
E
H
L
H
G
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
73.3
N.A.
53.3
46.6
N.A.
53.3
6.6
33.3
33.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
73.3
73.3
N.A.
66.6
13.3
66.6
66.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
17
0
0
0
0
0
0
0
34
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
42
9
0
0
50
9
0
0
0
0
0
0
0
% D
% Glu:
9
67
17
0
0
25
25
0
9
9
17
9
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
25
% F
% Gly:
9
0
0
0
84
0
9
0
0
0
0
0
0
17
0
% G
% His:
0
0
0
0
0
0
0
0
0
17
9
0
9
0
0
% H
% Ile:
0
9
9
0
0
9
0
0
59
0
0
0
9
0
9
% I
% Lys:
9
0
0
0
9
9
0
0
0
0
0
0
42
0
9
% K
% Leu:
25
0
0
0
0
0
9
0
17
50
0
25
0
17
17
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
17
0
0
0
0
0
0
9
0
0
0
50
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% P
% Gln:
42
17
0
0
0
50
0
0
0
9
9
50
9
0
9
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
0
0
25
0
9
% R
% Ser:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
9
% S
% Thr:
0
0
0
0
9
0
0
0
0
9
17
17
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
17
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
84
0
0
0
84
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _