KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
8.18
Human Site:
Y337
Identified Species:
16.36
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
Y337
L
A
K
S
P
F
A
Y
Y
T
P
G
K
G
A
Chimpanzee
Pan troglodytes
XP_511130
387
42727
Y337
S
A
K
S
P
F
A
Y
Y
T
P
G
K
G
A
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
Y336
S
A
K
S
P
F
A
Y
Y
T
P
G
K
A
A
Dog
Lupus familis
XP_546810
382
41989
F338
S
A
K
S
P
F
A
F
Y
A
P
G
A
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
F338
S
A
R
N
P
S
S
F
Y
Y
P
G
R
M
A
Rat
Rattus norvegicus
Q62730
381
41949
F338
C
A
K
N
P
S
S
F
Y
C
S
G
R
M
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
L329
L
S
K
H
S
F
A
L
Y
T
P
G
K
N
S
Chicken
Gallus gallus
Q5ZJZ5
339
38218
E296
T
D
T
S
P
V
I
E
S
V
A
H
A
L
T
Frog
Xenopus laevis
NP_001086062
388
43271
K341
L
S
E
N
P
K
V
K
Y
Y
A
G
K
N
L
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
R326
L
S
P
Q
P
Q
V
R
Y
Y
A
G
P
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
K282
I
L
Q
C
I
L
R
K
E
P
D
I
I
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
R337
L
A
A
Q
P
R
S
R
Y
Y
T
G
R
G
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
86.6
66.6
N.A.
40
33.3
N.A.
60
13.3
33.3
33.3
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
86.6
73.3
N.A.
73.3
60
N.A.
73.3
13.3
53.3
40
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
59
9
0
0
0
42
0
0
9
25
0
17
9
42
% A
% Cys:
9
0
0
9
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
0
9
0
0
0
0
9
9
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
42
0
25
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
84
0
34
0
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
9
0
0
0
9
0
9
0
0
0
0
9
9
0
0
% I
% Lys:
0
0
50
0
0
9
0
17
0
0
0
0
42
0
0
% K
% Leu:
42
9
0
0
0
9
0
9
0
0
0
0
0
17
25
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% M
% Asn:
0
0
0
25
0
0
0
0
0
0
0
0
0
17
0
% N
% Pro:
0
0
9
0
84
0
0
0
0
9
50
0
9
0
0
% P
% Gln:
0
0
9
17
0
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
9
0
0
9
9
17
0
0
0
0
25
0
0
% R
% Ser:
34
25
0
42
9
17
25
0
9
0
9
0
0
0
17
% S
% Thr:
9
0
9
0
0
0
0
0
0
34
9
0
0
0
17
% T
% Val:
0
0
0
0
0
9
17
0
0
9
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
25
84
34
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _