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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
15.45
Human Site:
Y359
Identified Species:
30.91
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
Y359
H
Y
L
P
I
G
I
Y
D
Y
F
A
K
R
H
Chimpanzee
Pan troglodytes
XP_511130
387
42727
Y359
H
Y
L
P
I
G
I
Y
D
Y
F
A
K
R
H
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
Y358
F
Y
L
P
I
G
I
Y
N
Y
F
A
E
R
N
Dog
Lupus familis
XP_546810
382
41989
F360
S
F
S
P
T
G
I
F
D
Y
F
S
K
K
L
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
L360
A
Y
C
P
T
S
L
L
D
Y
V
I
K
K
G
Rat
Rattus norvegicus
Q62730
381
41949
L360
A
Y
S
P
I
S
L
L
D
Y
I
L
K
N
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
S351
S
F
F
P
I
W
V
S
D
A
L
I
K
T
F
Chicken
Gallus gallus
Q5ZJZ5
339
38218
W318
Y
H
P
M
D
Y
Y
W
W
L
R
M
Q
I
M
Frog
Xenopus laevis
NP_001086062
388
43271
S363
I
Y
L
P
H
S
L
S
D
N
F
C
K
S
L
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
S348
S
Y
L
P
L
S
I
S
D
R
F
L
Q
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
P304
Y
Y
L
R
H
L
C
P
S
L
Y
F
W
I
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
R359
H
Y
L
P
G
G
L
R
R
R
F
L
Q
N
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
73.3
46.6
N.A.
33.3
40
N.A.
26.6
0
40
40
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
73.3
N.A.
46.6
53.3
N.A.
40
26.6
46.6
60
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
0
0
0
0
0
9
0
25
0
0
0
% A
% Cys:
0
0
9
0
0
0
9
0
0
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
0
67
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
9
17
9
0
0
0
0
9
0
0
59
9
0
0
17
% F
% Gly:
0
0
0
0
9
42
0
0
0
0
0
0
0
0
9
% G
% His:
25
9
0
0
17
0
0
0
0
0
0
0
0
0
17
% H
% Ile:
9
0
0
0
42
0
42
0
0
0
9
17
0
17
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
59
25
0
% K
% Leu:
0
0
59
0
9
9
34
17
0
17
9
25
0
0
25
% L
% Met:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
17
% M
% Asn:
0
0
0
0
0
0
0
0
9
9
0
0
0
17
9
% N
% Pro:
0
0
9
84
0
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
0
% Q
% Arg:
0
0
0
9
0
0
0
9
9
17
9
0
0
25
0
% R
% Ser:
25
0
17
0
0
34
0
25
9
0
0
9
0
9
0
% S
% Thr:
0
0
0
0
17
0
0
0
0
0
0
0
0
9
0
% T
% Val:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
9
9
0
0
0
9
0
0
% W
% Tyr:
17
75
0
0
0
9
9
25
0
50
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _