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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIGA All Species: 15.15
Human Site: Y26 Identified Species: 23.81
UniProt: P37287 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P37287 NP_002632.1 484 54127 Y26 R V S P G S L Y T C R T R T H
Chimpanzee Pan troglodytes XP_520945 484 54135 Y26 R V S P G S L Y T C R T R T H
Rhesus Macaque Macaca mulatta XP_001100879 484 54016 S26 R V S P G S L S T C R T H A H
Dog Lupus familis XP_548868 485 54195 S26 R V S P G S L S A Y R T R T H
Cat Felis silvestris
Mouse Mus musculus Q64323 485 54450 S26 P G S S G N L S D D R T C T H
Rat Rattus norvegicus NP_001102286 252 28487
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515555 485 54365 P26 H V N C G T R P A C R P P M H
Chicken Gallus gallus NP_001025979 477 53438 E24 Y P N M G G V E S H I Y Q L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001119918 487 54140 D30 S N T V Q H A D H E Q S V K H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397085 442 50212 G20 D F F Y P N M G G V E E H I F
Nematode Worm Caenorhab. elegans NP_495840 444 49466 A21 S D F F C P N A G G V E T H I
Sea Urchin Strong. purpuratus XP_789293 461 51539 E20 F P N T G G V E S H I Y Q L S
Poplar Tree Populus trichocarpa XP_002323038 433 49503 F11 L M V S D F F F P N F G G V E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_566874 447 50406 G21 D F F F P N F G G V E N H I Y
Baker's Yeast Sacchar. cerevisiae P32363 452 51224 Y24 G G V E F H I Y H L S Q K L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 95.6 92.9 N.A. 87.6 45.4 N.A. 88.4 83.4 N.A. 73.3 N.A. N.A. 52.8 49.5 55.9
Protein Similarity: 100 100 98.3 95.8 N.A. 93.4 49.7 N.A. 93.1 90 N.A. 83.7 N.A. N.A. 67.9 65 71
P-Site Identity: 100 100 80 80 N.A. 46.6 0 N.A. 33.3 6.6 N.A. 6.6 N.A. N.A. 0 0 6.6
P-Site Similarity: 100 100 80 80 N.A. 53.3 0 N.A. 46.6 33.3 N.A. 26.6 N.A. N.A. 13.3 0 33.3
Percent
Protein Identity: 46.9 N.A. N.A. 48.9 42.3 N.A.
Protein Similarity: 63.8 N.A. N.A. 66.7 61.3 N.A.
P-Site Identity: 0 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 7 14 0 0 0 0 7 0 % A
% Cys: 0 0 0 7 7 0 0 0 0 27 0 0 7 0 0 % C
% Asp: 14 7 0 0 7 0 0 7 7 7 0 0 0 0 0 % D
% Glu: 0 0 0 7 0 0 0 14 0 7 14 14 0 0 7 % E
% Phe: 7 14 20 14 7 7 14 7 0 0 7 0 0 0 7 % F
% Gly: 7 14 0 0 54 14 0 14 20 7 0 7 7 0 0 % G
% His: 7 0 0 0 0 14 0 0 14 14 0 0 20 7 47 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 14 0 0 14 14 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 7 7 0 % K
% Leu: 7 0 0 0 0 0 34 0 0 7 0 0 0 20 0 % L
% Met: 0 7 0 7 0 0 7 0 0 0 0 0 0 7 0 % M
% Asn: 0 7 20 0 0 20 7 0 0 7 0 7 0 0 0 % N
% Pro: 7 14 0 27 14 7 0 7 7 0 0 7 7 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 7 7 14 0 0 % Q
% Arg: 27 0 0 0 0 0 7 0 0 0 40 0 20 0 0 % R
% Ser: 14 0 34 14 0 27 0 20 14 0 7 7 0 0 14 % S
% Thr: 0 0 7 7 0 7 0 0 20 0 0 34 7 27 0 % T
% Val: 0 34 14 7 0 0 14 0 0 14 7 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 7 0 0 0 20 0 7 0 14 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _