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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LIPA
All Species:
29.7
Human Site:
Y280
Identified Species:
54.44
UniProt:
P38571
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P38571
NP_000226.2
399
45419
Y280
N
M
S
R
V
D
V
Y
T
T
H
S
P
A
G
Chimpanzee
Pan troglodytes
XP_521552
452
51086
Y333
N
M
S
R
V
D
V
Y
T
T
H
S
P
A
G
Rhesus Macaque
Macaca mulatta
XP_001085504
399
45462
Y280
N
M
S
R
V
D
V
Y
T
T
H
S
P
A
G
Dog
Lupus familis
XP_853280
398
45044
Y279
N
M
S
R
V
P
V
Y
I
S
H
S
P
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0M5
397
45532
Y278
N
M
S
R
V
D
V
Y
T
T
H
C
P
A
E
Rat
Rattus norvegicus
Q64194
397
45167
Y278
N
M
S
R
V
D
V
Y
T
T
H
C
P
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506638
397
45066
Y276
N
M
S
R
A
N
V
Y
V
A
H
A
P
A
G
Chicken
Gallus gallus
XP_421661
373
42666
Y254
N
M
S
R
V
D
V
Y
S
S
H
C
P
A
G
Frog
Xenopus laevis
NP_001089697
404
45661
V285
L
N
M
S
R
V
D
V
Y
S
S
H
C
P
S
Zebra Danio
Brachydanio rerio
NP_998569
396
44722
V277
L
N
M
S
R
T
P
V
Y
T
A
H
C
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O46108
394
44883
H273
L
D
Y
E
L
L
E
H
I
K
A
T
S
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q67ZU1
418
46029
F293
N
A
S
T
I
D
L
F
L
A
N
E
P
Q
S
Baker's Yeast
Sacchar. cerevisiae
P34163
548
62961
S304
L
P
R
Q
K
I
A
S
Y
A
K
L
Y
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.4
97.9
78.1
N.A.
72.6
74.9
N.A.
63.4
66.6
66.5
61.9
N.A.
38
N.A.
N.A.
N.A.
Protein Similarity:
100
85.1
98.7
88.9
N.A.
84.9
87.7
N.A.
75.9
79.4
80.9
74.1
N.A.
56.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
86.6
93.3
N.A.
66.6
80
0
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
93.3
N.A.
80
93.3
6.6
6.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.2
27.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.5
40.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
8
0
0
24
16
8
0
62
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
24
16
0
0
% C
% Asp:
0
8
0
0
0
54
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
8
0
0
0
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% G
% His:
0
0
0
0
0
0
0
8
0
0
62
16
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
0
16
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
8
8
0
0
0
0
% K
% Leu:
31
0
0
0
8
8
8
0
8
0
0
8
0
0
0
% L
% Met:
0
62
16
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
70
16
0
0
0
8
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
8
0
0
0
8
8
0
0
0
0
0
70
24
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
8
62
16
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
70
16
0
0
0
8
8
24
8
31
8
8
16
% S
% Thr:
0
0
0
8
0
8
0
0
39
47
0
8
0
0
8
% T
% Val:
0
0
0
0
54
8
62
16
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
62
24
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _