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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A3
All Species:
32.42
Human Site:
T178
Identified Species:
59.44
UniProt:
P38919
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P38919
NP_055555.1
411
46871
T178
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Chimpanzee
Pan troglodytes
XP_511724
543
61650
T310
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_533130
411
46792
T178
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q91VC3
411
46821
T178
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZM36
412
46797
T179
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Frog
Xenopus laevis
Q5U526
415
46962
T182
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Zebra Danio
Brachydanio rerio
Q7ZVA6
406
46449
T173
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649788
399
45626
D175
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
Honey Bee
Apis mellifera
XP_393356
403
46205
M175
L
R
T
R
A
I
K
M
L
V
L
D
E
S
D
Nematode Worm
Caenorhab. elegans
NP_490761
399
45564
D175
A
I
K
L
L
V
L
D
E
A
D
E
M
L
N
Sea Urchin
Strong. purpuratus
XP_785431
360
41204
Y156
Q
I
Y
D
V
Y
R
Y
L
P
P
A
T
Q
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A52
408
45826
T175
I
K
R
R
S
L
R
T
R
A
I
K
L
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q9P735
400
45389
D175
H
I
K
M
L
V
L
D
E
A
D
E
L
L
N
Conservation
Percent
Protein Identity:
100
75.5
N.A.
99.5
N.A.
99.2
N.A.
N.A.
N.A.
97.3
95.9
95.8
N.A.
85.4
86.1
84.4
82.2
Protein Similarity:
100
75.5
N.A.
99.5
N.A.
99.5
N.A.
N.A.
N.A.
98.5
96.8
96.8
N.A.
91.9
93.6
92.2
86.1
P-Site Identity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
20
13.3
20
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
40
46.6
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
74.7
N.A.
78.3
Protein Similarity:
N.A.
N.A.
N.A.
87.8
N.A.
89.5
P-Site Identity:
N.A.
N.A.
N.A.
80
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
100
N.A.
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
8
0
0
0
0
85
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
24
0
0
24
8
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
24
0
0
24
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
62
31
0
0
0
8
0
0
0
0
62
0
0
0
8
% I
% Lys:
0
8
24
0
0
0
8
0
0
0
0
62
0
0
0
% K
% Leu:
8
0
0
8
24
62
24
0
16
0
8
0
16
85
0
% L
% Met:
0
0
0
16
0
0
0
8
0
0
0
0
70
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
62
62
70
0
0
70
0
62
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
62
0
0
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
8
0
0
0
0
62
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
8
24
0
0
0
8
0
0
0
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _