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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A3
All Species:
23.64
Human Site:
Y56
Identified Species:
43.33
UniProt:
P38919
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P38919
NP_055555.1
411
46871
Y56
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Chimpanzee
Pan troglodytes
XP_511724
543
61650
Y188
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_533130
411
46792
Y56
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q91VC3
411
46821
Y56
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZM36
412
46797
Y57
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Frog
Xenopus laevis
Q5U526
415
46962
Y60
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Zebra Danio
Brachydanio rerio
Q7ZVA6
406
46449
P56
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649788
399
45626
T58
A
I
Q
Q
R
S
I
T
P
I
V
K
G
R
D
Honey Bee
Apis mellifera
XP_393356
403
46205
I56
G
F
E
K
P
S
A
I
Q
Q
R
S
I
K
P
Nematode Worm
Caenorhab. elegans
NP_490761
399
45564
A56
P
S
A
I
Q
Q
R
A
I
P
A
I
L
K
A
Sea Urchin
Strong. purpuratus
XP_785431
360
41204
F41
G
T
G
K
T
A
T
F
S
I
S
I
L
Q
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A52
408
45826
E56
G
V
Y
E
Y
G
F
E
K
P
S
A
I
Q
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q9P735
400
45389
A56
P
S
A
V
Q
S
R
A
I
V
Q
I
C
K
G
Conservation
Percent
Protein Identity:
100
75.5
N.A.
99.5
N.A.
99.2
N.A.
N.A.
N.A.
97.3
95.9
95.8
N.A.
85.4
86.1
84.4
82.2
Protein Similarity:
100
75.5
N.A.
99.5
N.A.
99.5
N.A.
N.A.
N.A.
98.5
96.8
96.8
N.A.
91.9
93.6
92.2
86.1
P-Site Identity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
100
100
13.3
N.A.
6.6
6.6
6.6
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
100
100
20
N.A.
20
6.6
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
74.7
N.A.
78.3
Protein Similarity:
N.A.
N.A.
N.A.
87.8
N.A.
89.5
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
0
0
8
54
16
0
8
8
8
0
0
62
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
8
8
0
8
0
8
0
0
47
0
0
0
0
% E
% Phe:
0
8
0
0
8
0
8
8
0
47
0
0
0
0
0
% F
% Gly:
24
0
8
54
0
8
0
0
47
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
47
0
8
8
16
16
8
24
16
0
0
% I
% Lys:
0
0
0
16
0
0
8
0
8
0
0
54
0
24
0
% K
% Leu:
47
47
0
0
0
0
0
0
0
0
0
0
16
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
16
0
0
0
8
0
0
8
8
16
0
0
47
0
8
% P
% Gln:
0
0
8
8
16
8
0
0
8
8
8
8
8
16
8
% Q
% Arg:
0
0
47
0
8
0
16
0
0
0
8
0
0
16
0
% R
% Ser:
0
16
0
0
0
24
0
0
16
0
16
8
0
47
0
% S
% Thr:
0
8
0
0
8
0
8
8
0
0
0
0
0
0
0
% T
% Val:
0
8
0
8
0
0
0
0
0
8
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
16
0
8
47
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _