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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IL6ST
All Species:
18.18
Human Site:
S857
Identified Species:
44.44
UniProt:
P40189
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40189
NP_002175.2
918
103537
S857
Q
Q
I
S
D
H
I
S
Q
S
C
G
S
G
Q
Chimpanzee
Pan troglodytes
XP_001144341
918
103578
S857
Q
Q
I
S
D
H
I
S
Q
S
C
G
S
G
Q
Rhesus Macaque
Macaca mulatta
XP_001100601
918
103709
S857
Q
Q
I
S
D
H
I
S
Q
S
C
G
S
G
E
Dog
Lupus familis
XP_535239
857
96713
Q797
Q
Q
I
S
D
I
S
Q
P
Y
G
S
G
Q
M
Cat
Felis silvestris
Mouse
Mus musculus
Q00560
917
102434
S856
Q
Q
V
S
D
H
I
S
Q
P
Y
G
S
E
Q
Rat
Rattus norvegicus
P40190
918
102432
S857
Q
Q
V
S
D
H
I
S
E
P
Y
G
S
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505316
793
88837
P733
I
R
L
T
Q
P
I
P
G
Q
S
S
G
P
C
Chicken
Gallus gallus
NP_990202
918
102477
S857
L
Q
I
S
G
Q
S
S
Q
P
L
G
F
E
L
Frog
Xenopus laevis
NP_001124412
881
98985
H820
T
N
K
L
Q
A
L
H
Q
E
E
P
S
H
F
Zebra Danio
Brachydanio rerio
NP_001106976
866
98131
E806
T
Q
P
L
L
D
C
E
E
H
P
E
N
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.5
85.9
N.A.
77
78.6
N.A.
56.6
59.4
44.9
35.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.6
88.8
N.A.
86.7
87.4
N.A.
67
72.2
58.2
51.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
33.3
N.A.
73.3
66.6
N.A.
6.6
40
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
80
80
N.A.
26.6
40
20
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
30
0
0
0
10
% C
% Asp:
0
0
0
0
60
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
20
10
10
10
0
30
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% F
% Gly:
0
0
0
0
10
0
0
0
10
0
10
60
20
30
0
% G
% His:
0
0
0
0
0
50
0
10
0
10
0
0
0
20
0
% H
% Ile:
10
0
50
0
0
10
60
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
10
20
10
0
10
0
0
0
10
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
10
0
0
10
0
10
10
30
10
10
0
10
10
% P
% Gln:
60
80
0
0
20
10
0
10
60
10
0
0
0
10
40
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
70
0
0
20
60
0
30
10
20
60
0
0
% S
% Thr:
20
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
20
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _