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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MPL
All Species:
6.67
Human Site:
T546
Identified Species:
20.95
UniProt:
P40238
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40238
NP_005364.1
635
71245
T546
L
G
Q
Y
L
R
D
T
A
A
L
S
P
P
K
Chimpanzee
Pan troglodytes
XP_001173359
327
36219
G239
S
A
L
T
A
E
G
G
S
C
L
I
S
G
L
Rhesus Macaque
Macaca mulatta
XP_001105833
508
55076
S420
K
P
S
P
E
G
A
S
A
A
S
F
E
Y
T
Dog
Lupus familis
XP_853442
435
48920
F347
P
G
L
Q
P
S
R
F
S
R
C
H
F
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q08351
625
69799
T537
L
G
Q
Y
L
R
D
T
A
A
L
S
P
S
K
Rat
Rattus norvegicus
Q07303
507
55481
S419
K
P
R
P
E
G
T
S
P
S
S
F
E
Y
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512701
492
54148
P404
H
A
Q
D
C
R
G
P
G
H
S
E
C
G
T
Chicken
Gallus gallus
NP_001001782
630
68838
S530
C
T
F
P
S
L
Y
S
S
V
K
Q
R
L
W
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.3
21.7
57
N.A.
80.6
22.2
N.A.
36.8
36.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
51.5
33.2
60.9
N.A.
85.3
32.4
N.A.
48.9
49.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
13.3
6.6
N.A.
93.3
0
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
20
13.3
N.A.
93.3
20
N.A.
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
25
0
0
13
0
13
0
38
38
0
0
0
0
0
% A
% Cys:
13
0
0
0
13
0
0
0
0
13
13
0
13
0
0
% C
% Asp:
0
0
0
13
0
0
25
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
25
13
0
0
0
0
0
13
25
0
0
% E
% Phe:
0
0
13
0
0
0
0
13
0
0
0
25
13
0
0
% F
% Gly:
0
38
0
0
0
25
25
13
13
0
0
0
0
25
0
% G
% His:
13
0
0
0
0
0
0
0
0
13
0
13
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% I
% Lys:
25
0
0
0
0
0
0
0
0
0
13
0
0
13
25
% K
% Leu:
25
0
25
0
25
13
0
0
0
0
38
0
0
13
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
13
25
0
38
13
0
0
13
13
0
0
0
25
13
0
% P
% Gln:
0
0
38
13
0
0
0
0
0
0
0
13
0
0
0
% Q
% Arg:
0
0
13
0
0
38
13
0
0
13
0
0
13
0
0
% R
% Ser:
13
0
13
0
13
13
0
38
38
13
38
25
13
13
13
% S
% Thr:
0
13
0
13
0
0
13
25
0
0
0
0
0
0
38
% T
% Val:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% W
% Tyr:
0
0
0
25
0
0
13
0
0
0
0
0
0
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _