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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARL4A All Species: 19.09
Human Site: S141 Identified Species: 24.71
UniProt: P40617 Number Species: 17
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40617 NP_001032241.1 200 22615 S141 N K Q D L R N S L S L S E I E
Chimpanzee Pan troglodytes XP_001147147 220 24954 S141 N K Q D L R N S L S L S E I E
Rhesus Macaque Macaca mulatta XP_001099050 200 22556 S141 N K Q D L R N S L S L S E I E
Dog Lupus familis XP_548073 201 22148 A142 N K Q D Q P G A L S A A E V E
Cat Felis silvestris
Mouse Mus musculus Q99PE9 201 22223 A142 N K Q D Q P G A L S A A E V E
Rat Rattus norvegicus P61214 200 22570 S141 N K Q D L R N S L S L S E I E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519864 193 21567 S135 N K Q D L P K S L P V A E I E
Chicken Gallus gallus P26990 175 20078 G140 H E I Q E K L G L T R I R D R
Frog Xenopus laevis P51644 180 20567 K142 A I S E M T D K L T L Q T L R
Zebra Danio Brachydanio rerio NP_956612 201 22867 A142 N K Q D L R S A L P L S E V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40946 175 19987 K138 K P H E I Q E K L G L T R I R
Honey Bee Apis mellifera XP_001120491 207 22359 V147 D L P G A K E V G E L E K H L
Nematode Worm Caenorhab. elegans Q10943 181 20503 K142 N A A E V T D K L G L H S L R
Sea Urchin Strong. purpuratus XP_785283 193 21506 I145 T I E E A L T I P A L R K Q Q
Poplar Tree Populus trichocarpa
Maize Zea mays P49076 181 20642 K142 N A A E I T D K L G L N S L R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SHU5 205 23062 T158 R C W L I Q G T S A I S G Q G
Baker's Yeast Sacchar. cerevisiae P11076 181 20511 K142 S A A E I T E K L G L H S I R
Red Bread Mold Neurospora crassa Q7RVM2 185 20961 A136 N K Q D L P N A M N A A E I T
Conservation
Percent
Protein Identity: 100 89 99 60.2 N.A. 60.7 99.5 N.A. 68 42 42.5 80 N.A. 42 54.1 40 50.5
Protein Similarity: 100 90.9 99.5 80 N.A. 81 100 N.A. 85.5 58 62 89.5 N.A. 59 70.5 59.5 69.5
P-Site Identity: 100 100 100 53.3 N.A. 53.3 100 N.A. 66.6 6.6 13.3 73.3 N.A. 20 6.6 20 6.6
P-Site Similarity: 100 100 100 73.3 N.A. 73.3 100 N.A. 80 33.3 46.6 93.3 N.A. 46.6 26.6 46.6 40
Percent
Protein Identity: N.A. 40.5 N.A. 43.4 39.5 42
Protein Similarity: N.A. 60.5 N.A. 59.5 58 60
P-Site Identity: N.A. 20 N.A. 6.6 20 53.3
P-Site Similarity: N.A. 53.3 N.A. 40 40 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 17 17 0 12 0 0 23 0 12 17 23 0 0 0 % A
% Cys: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 6 0 0 50 0 0 17 0 0 0 0 0 0 6 0 % D
% Glu: 0 6 6 34 6 0 17 0 0 6 0 6 50 0 45 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 6 0 0 17 6 6 23 0 0 6 0 6 % G
% His: 6 0 6 0 0 0 0 0 0 0 0 12 0 6 0 % H
% Ile: 0 12 6 0 23 0 0 6 0 0 6 6 0 45 0 % I
% Lys: 6 50 0 0 0 12 6 28 0 0 0 0 12 0 0 % K
% Leu: 0 6 0 6 39 6 6 0 78 0 67 0 0 17 6 % L
% Met: 0 0 0 0 6 0 0 0 6 0 0 0 0 0 0 % M
% Asn: 62 0 0 0 0 0 28 0 0 6 0 6 0 0 0 % N
% Pro: 0 6 6 0 0 23 0 0 6 12 0 0 0 0 0 % P
% Gln: 0 0 50 6 12 12 0 0 0 0 0 6 0 12 6 % Q
% Arg: 6 0 0 0 0 28 0 0 0 0 6 6 12 0 34 % R
% Ser: 6 0 6 0 0 0 6 28 6 34 0 34 17 0 0 % S
% Thr: 6 0 0 0 0 23 6 6 0 12 0 6 6 0 6 % T
% Val: 0 0 0 0 6 0 0 6 0 0 6 0 0 17 0 % V
% Trp: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _