Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH1 All Species: 18.48
Human Site: S362 Identified Species: 33.89
UniProt: P40692 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40692 NP_000240.1 756 84601 S362 P S G E M V K S T T S L T S S
Chimpanzee Pan troglodytes XP_001170274 756 84655 S362 P S G E M V K S T T S L T S S
Rhesus Macaque Macaca mulatta XP_001087274 583 64794 T212 R T L P N A S T V D N I R S I
Dog Lupus familis XP_534219 757 84567 S362 P S G E V V K S T T G A T P S
Cat Felis silvestris
Mouse Mus musculus Q9JK91 760 84662 P362 P S G E A A R P T T G V A S S
Rat Rattus norvegicus P97679 757 84522 S362 P S G E A V K S T T G I A S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418828 757 84832 S362 S S S E V V K S A A S S S T A
Frog Xenopus laevis NP_001090545 750 84121 P359 C A S G F T K P L P A S S T S
Zebra Danio Brachydanio rerio NP_956953 724 80793 A353 L P G L S A S A S V A K A S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120100 716 81818 T341 S A N S A S R T F Y L K T R L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793318 745 83320 K359 S I A D D E D K S K G Q R S S
Poplar Tree Populus trichocarpa XP_002325965 747 83627 N353 L N Q E F I I N T I Q S A V E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38920 769 87044 T362 S L I P F N D T I E S D R N R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 76 93 N.A. 88.1 87 N.A. N.A. 80 75.1 69.7 N.A. N.A. 50.6 N.A. 60.3
Protein Similarity: 100 99.8 76.5 96.1 N.A. 93.9 93.3 N.A. N.A. 88.1 85.9 81 N.A. N.A. 70.7 N.A. 75.7
P-Site Identity: 100 100 6.6 73.3 N.A. 53.3 73.3 N.A. N.A. 40 13.3 20 N.A. N.A. 6.6 N.A. 13.3
P-Site Similarity: 100 100 33.3 80 N.A. 66.6 80 N.A. N.A. 66.6 40 40 N.A. N.A. 26.6 N.A. 26.6
Percent
Protein Identity: 34.7 N.A. N.A. N.A. 36 N.A.
Protein Similarity: 56.6 N.A. N.A. N.A. 58.5 N.A.
P-Site Identity: 13.3 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 33.3 N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 8 0 24 24 0 8 8 8 16 8 31 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 8 0 16 0 0 8 0 8 0 0 0 % D
% Glu: 0 0 0 54 0 8 0 0 0 8 0 0 0 0 8 % E
% Phe: 0 0 0 0 24 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 47 8 0 0 0 0 0 0 31 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 0 0 8 8 0 8 8 0 16 0 0 8 % I
% Lys: 0 0 0 0 0 0 47 8 0 8 0 16 0 0 0 % K
% Leu: 16 8 8 8 0 0 0 0 8 0 8 16 0 0 8 % L
% Met: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 8 8 0 8 0 0 8 0 0 8 0 % N
% Pro: 39 8 0 16 0 0 0 16 0 8 0 0 0 8 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 8 8 0 0 0 % Q
% Arg: 8 0 0 0 0 0 16 0 0 0 0 0 24 8 8 % R
% Ser: 31 47 16 8 8 8 16 39 16 0 31 24 16 54 62 % S
% Thr: 0 8 0 0 0 8 0 24 47 39 0 0 31 16 0 % T
% Val: 0 0 0 0 16 39 0 0 8 8 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _