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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH1 All Species: 26.67
Human Site: S508 Identified Species: 48.89
UniProt: P40692 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40692 NP_000240.1 756 84601 S508 I N L T S V L S L Q E E I N E
Chimpanzee Pan troglodytes XP_001170274 756 84655 S508 I N L T S V L S L Q E E I N E
Rhesus Macaque Macaca mulatta XP_001087274 583 64794 L348 R M Y F T Q T L L P G L A G P
Dog Lupus familis XP_534219 757 84567 S509 I N L T S V L S L Q E E I N E
Cat Felis silvestris
Mouse Mus musculus Q9JK91 760 84662 S512 I N L T S V L S L Q E E I S E
Rat Rattus norvegicus P97679 757 84522 S510 I N L T S V L S L Q E E I N D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418828 757 84832 T509 I N L T S V L T L Q E E I S N
Frog Xenopus laevis NP_001090545 750 84121 S504 I N L T S I L S L Q K E I E E
Zebra Danio Brachydanio rerio NP_956953 724 80793 L489 G L R D Q I E L Q T H K G L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120100 716 81818 K478 T S D L R E V K L T S V L K L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793318 745 83320 E497 I Q L T S V L E L Q K E I E D
Poplar Tree Populus trichocarpa XP_002325965 747 83627 G490 V R N C T Y I G M A D D V F A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38920 769 87044 K516 V N L T S I K K L R E K V D D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 76 93 N.A. 88.1 87 N.A. N.A. 80 75.1 69.7 N.A. N.A. 50.6 N.A. 60.3
Protein Similarity: 100 99.8 76.5 96.1 N.A. 93.9 93.3 N.A. N.A. 88.1 85.9 81 N.A. N.A. 70.7 N.A. 75.7
P-Site Identity: 100 100 6.6 100 N.A. 93.3 93.3 N.A. N.A. 80 80 0 N.A. N.A. 6.6 N.A. 66.6
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. N.A. 93.3 93.3 20 N.A. N.A. 26.6 N.A. 80
Percent
Protein Identity: 34.7 N.A. N.A. N.A. 36 N.A.
Protein Similarity: 56.6 N.A. N.A. N.A. 58.5 N.A.
P-Site Identity: 0 N.A. N.A. N.A. 40 N.A.
P-Site Similarity: 46.6 N.A. N.A. N.A. 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 0 0 0 0 0 0 8 8 0 8 24 % D
% Glu: 0 0 0 0 0 8 8 8 0 0 54 62 0 16 39 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 8 0 0 0 0 0 0 8 0 0 8 0 8 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 62 0 0 0 0 24 8 0 0 0 0 0 62 0 0 % I
% Lys: 0 0 0 0 0 0 8 16 0 0 16 16 0 8 0 % K
% Leu: 0 8 70 8 0 0 62 16 85 0 0 8 8 8 8 % L
% Met: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 62 8 0 0 0 0 0 0 0 0 0 0 31 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % P
% Gln: 0 8 0 0 8 8 0 0 8 62 0 0 0 0 8 % Q
% Arg: 8 8 8 0 8 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 8 0 0 70 0 0 47 0 0 8 0 0 16 0 % S
% Thr: 8 0 0 70 16 0 8 8 0 16 0 0 0 0 0 % T
% Val: 16 0 0 0 0 54 8 0 0 0 0 8 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _