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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLH1 All Species: 27.88
Human Site: Y721 Identified Species: 51.11
UniProt: P40692 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40692 NP_000240.1 756 84601 Y721 W T V E H I V Y K A L R S H I
Chimpanzee Pan troglodytes XP_001170274 756 84655 Y721 W T V E H I V Y K A L R S H I
Rhesus Macaque Macaca mulatta XP_001087274 583 64794 L549 Q H Q T K L Y L L N T T K L S
Dog Lupus familis XP_534219 757 84567 Y722 W T V E H I V Y K A F R S H L
Cat Felis silvestris
Mouse Mus musculus Q9JK91 760 84662 Y725 W T V E H I I Y K A F R S H L
Rat Rattus norvegicus P97679 757 84522 Y722 W T V E H I I Y K A F R S H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418828 757 84832 Y722 W T V E H V V Y K A F R T H L
Frog Xenopus laevis NP_001090545 750 84121 Y715 W T T E H I L Y K A F R T H L
Zebra Danio Brachydanio rerio NP_956953 724 80793 K690 K V E H V L F K A L R S L F S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120100 716 81818 Y681 Y I T E H V L Y S T I K E S F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793318 745 83320 F710 W T I E F V I F P A L K S T L
Poplar Tree Populus trichocarpa XP_002325965 747 83627 F712 W S I Q H V L F P S M R L F L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38920 769 87044 V734 I S S L L E H V L F P C I K R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 76 93 N.A. 88.1 87 N.A. N.A. 80 75.1 69.7 N.A. N.A. 50.6 N.A. 60.3
Protein Similarity: 100 99.8 76.5 96.1 N.A. 93.9 93.3 N.A. N.A. 88.1 85.9 81 N.A. N.A. 70.7 N.A. 75.7
P-Site Identity: 100 100 0 86.6 N.A. 80 80 N.A. N.A. 73.3 66.6 0 N.A. N.A. 20 N.A. 40
P-Site Similarity: 100 100 6.6 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 6.6 N.A. N.A. 53.3 N.A. 80
Percent
Protein Identity: 34.7 N.A. N.A. N.A. 36 N.A.
Protein Similarity: 56.6 N.A. N.A. N.A. 58.5 N.A.
P-Site Identity: 20 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 80 N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 62 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 70 0 8 0 0 0 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 8 0 8 16 0 8 39 0 0 16 8 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 8 70 0 8 0 0 0 0 0 0 54 0 % H
% Ile: 8 8 16 0 0 47 24 0 0 0 8 0 8 0 16 % I
% Lys: 8 0 0 0 8 0 0 8 54 0 0 16 8 8 0 % K
% Leu: 0 0 0 8 8 16 24 8 16 8 24 0 16 8 54 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 16 0 8 0 0 0 0 % P
% Gln: 8 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 62 0 0 8 % R
% Ser: 0 16 8 0 0 0 0 0 8 8 0 8 47 8 16 % S
% Thr: 0 62 16 8 0 0 0 0 0 8 8 8 16 8 0 % T
% Val: 0 8 47 0 8 31 31 8 0 0 0 0 0 0 0 % V
% Trp: 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 62 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _