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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
28.18
Human Site:
S218
Identified Species:
47.69
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
S218
Q
D
S
C
I
L
H
S
L
S
V
P
E
E
A
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
S218
Q
D
S
C
I
L
H
S
L
S
V
P
E
E
A
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
S218
Q
D
S
C
I
L
H
S
L
S
V
P
E
E
A
Dog
Lupus familis
XP_535474
1116
127497
S218
Q
D
S
H
I
S
N
S
L
C
V
P
E
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
S218
Q
H
S
C
I
L
D
S
L
S
V
P
E
E
A
Rat
Rattus norvegicus
NP_001099972
1081
122532
H212
R
K
I
Q
D
Y
Q
H
S
C
I
L
G
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
S214
Q
T
S
S
I
V
N
S
L
C
V
P
E
E
A
Chicken
Gallus gallus
XP_413830
1116
127997
S218
Q
E
S
C
I
P
R
S
V
S
V
P
E
E
A
Frog
Xenopus laevis
NP_001080551
1063
120542
S214
E
E
S
H
I
R
T
S
I
S
V
P
Q
E
A
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
P211
Q
E
S
Q
I
S
V
P
S
Q
T
C
I
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
M66
T
Y
M
K
Y
F
N
M
L
T
A
I
H
K
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
I206
F
K
D
S
H
M
T
I
G
Q
C
I
S
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
P80
S
E
A
S
R
P
G
P
I
D
N
H
D
I
I
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
Y96
I
I
Q
L
N
Y
V
Y
Y
K
V
I
H
I
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
73.3
N.A.
86.6
0
N.A.
66.6
73.3
53.3
20
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
100
80
N.A.
86.6
13.3
N.A.
80
86.6
80
26.6
N.A.
26.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
58
% A
% Cys:
0
0
0
36
0
0
0
0
0
22
8
8
0
0
0
% C
% Asp:
0
29
8
0
8
0
8
0
0
8
0
0
8
0
0
% D
% Glu:
8
29
0
0
0
0
0
0
0
0
0
0
50
58
0
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
8
0
0
0
8
0
0
% G
% His:
0
8
0
15
8
0
22
8
0
0
0
8
15
0
0
% H
% Ile:
8
8
8
0
65
0
0
8
15
0
8
22
8
22
15
% I
% Lys:
0
15
0
8
0
0
0
0
0
8
0
0
0
8
8
% K
% Leu:
0
0
0
8
0
29
0
0
50
0
0
8
0
0
8
% L
% Met:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
22
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
15
0
15
0
0
0
58
0
0
8
% P
% Gln:
58
0
8
15
0
0
8
0
0
15
0
0
8
0
0
% Q
% Arg:
8
0
0
0
8
8
8
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
65
22
0
15
0
58
15
43
0
0
8
15
0
% S
% Thr:
8
8
0
0
0
0
15
0
0
8
8
0
0
0
0
% T
% Val:
0
0
0
0
0
8
15
0
8
0
65
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
8
15
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _