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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP8 All Species: 9.7
Human Site: S427 Identified Species: 16.41
UniProt: P40818 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40818 NP_001122082.1 1118 127523 S427 E H R I K S E S T N H E Q Q S
Chimpanzee Pan troglodytes XP_001168710 1118 127532 S427 E H R I K S E S T N H E Q Q S
Rhesus Macaque Macaca mulatta XP_001114466 1118 127660 S427 E H R T K S E S T N H E Q Q S
Dog Lupus familis XP_535474 1116 127497 N427 D H K I K S E N K D H E Q Q S
Cat Felis silvestris
Mouse Mus musculus Q80U87 1080 122592 N427 D H R I K S E N T D Q S G R V
Rat Rattus norvegicus NP_001099972 1081 122532 H421 A V K L P E D H R M K S E S T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507996 1116 126304 P423 V R A E S A E P D P K S L Q N
Chicken Gallus gallus XP_413830 1116 127997 T427 N K S K S E S T L S D S Q P I
Frog Xenopus laevis NP_001080551 1063 120542 K423 T V T E S T T K F K P E A K E
Zebra Danio Brachydanio rerio XP_693811 1099 124389 P420 H T P P L A P P A H T E A A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650948 896 102648 P275 E Y F I M M Y P T H C T N P S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784858 1187 131804 A415 S R D K P K F A P A P V A N L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93Y01 910 102631 N289 T S E D D G S N S L S I L G K
Baker's Yeast Sacchar. cerevisiae P32571 926 105173 D305 F E K P I S D D F T K I F I L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.3 91.8 N.A. 81.8 81.9 N.A. 76.9 74.4 59.9 53.5 N.A. 31.4 N.A. N.A. 39
Protein Similarity: 100 99.7 99.1 95.3 N.A. 88 87.7 N.A. 87 84.8 74.2 69.5 N.A. 47.7 N.A. N.A. 56.3
P-Site Identity: 100 100 93.3 66.6 N.A. 46.6 0 N.A. 13.3 6.6 6.6 6.6 N.A. 26.6 N.A. N.A. 0
P-Site Similarity: 100 100 93.3 93.3 N.A. 73.3 33.3 N.A. 26.6 20 20 26.6 N.A. 40 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 20.2 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 38.3 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 15 0 8 8 8 0 0 22 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 15 0 8 8 8 0 15 8 8 15 8 0 0 0 0 % D
% Glu: 29 8 8 15 0 15 43 0 0 0 0 43 8 0 8 % E
% Phe: 8 0 8 0 0 0 8 0 15 0 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 0 0 0 0 8 8 0 % G
% His: 8 36 0 0 0 0 0 8 0 15 29 0 0 0 0 % H
% Ile: 0 0 0 36 8 0 0 0 0 0 0 15 0 8 8 % I
% Lys: 0 8 22 15 36 8 0 8 8 8 22 0 0 8 8 % K
% Leu: 0 0 0 8 8 0 0 0 8 8 0 0 15 0 15 % L
% Met: 0 0 0 0 8 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 22 0 22 0 0 8 8 8 % N
% Pro: 0 0 8 15 15 0 8 22 8 8 15 0 0 15 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 36 36 0 % Q
% Arg: 0 15 29 0 0 0 0 0 8 0 0 0 0 8 0 % R
% Ser: 8 8 8 0 22 43 15 22 8 8 8 29 0 8 36 % S
% Thr: 15 8 8 8 0 8 8 8 36 8 8 8 0 0 8 % T
% Val: 8 15 0 0 0 0 0 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _