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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP8 All Species: 17.27
Human Site: S434 Identified Species: 29.23
UniProt: P40818 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40818 NP_001122082.1 1118 127523 S434 S T N H E Q Q S P Q S G K V I
Chimpanzee Pan troglodytes XP_001168710 1118 127532 S434 S T N H E Q Q S P Q S G K V I
Rhesus Macaque Macaca mulatta XP_001114466 1118 127660 S434 S T N H E Q Q S P Q N G K V I
Dog Lupus familis XP_535474 1116 127497 S434 N K D H E Q Q S P Q D G K V V
Cat Felis silvestris
Mouse Mus musculus Q80U87 1080 122592 V434 N T D Q S G R V L S D R S T K
Rat Rattus norvegicus NP_001099972 1081 122532 T428 H R M K S E S T D Q S G R V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507996 1116 126304 N430 P D P K S L Q N G K M V P D R
Chicken Gallus gallus XP_413830 1116 127997 I434 T L S D S Q P I E K G R V V P
Frog Xenopus laevis NP_001080551 1063 120542 E430 K F K P E A K E K Q A M L N G
Zebra Danio Brachydanio rerio XP_693811 1099 124389 A427 P A H T E A A A P P T A S P R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650948 896 102648 S282 P T H C T N P S V Q A P Q Q N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784858 1187 131804 L422 A P A P V A N L I T N N L E S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93Y01 910 102631 K296 N S L S I L G K G E K G G L A
Baker's Yeast Sacchar. cerevisiae P32571 926 105173 L312 D F T K I F I L E S G F P G W
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.3 91.8 N.A. 81.8 81.9 N.A. 76.9 74.4 59.9 53.5 N.A. 31.4 N.A. N.A. 39
Protein Similarity: 100 99.7 99.1 95.3 N.A. 88 87.7 N.A. 87 84.8 74.2 69.5 N.A. 47.7 N.A. N.A. 56.3
P-Site Identity: 100 100 93.3 66.6 N.A. 6.6 26.6 N.A. 6.6 13.3 13.3 13.3 N.A. 20 N.A. N.A. 0
P-Site Similarity: 100 100 100 86.6 N.A. 26.6 53.3 N.A. 20 33.3 26.6 33.3 N.A. 40 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 20.2 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 38.3 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 22 8 8 0 0 15 8 0 0 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 15 8 0 0 0 0 8 0 15 0 0 8 0 % D
% Glu: 0 0 0 0 43 8 0 8 15 8 0 0 0 8 0 % E
% Phe: 0 15 0 0 0 8 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 0 15 0 15 43 8 8 8 % G
% His: 8 0 15 29 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 15 0 8 8 8 0 0 0 0 0 22 % I
% Lys: 8 8 8 22 0 0 8 8 8 15 8 0 29 0 8 % K
% Leu: 0 8 8 0 0 15 0 15 8 0 0 0 15 8 8 % L
% Met: 0 0 8 0 0 0 0 0 0 0 8 8 0 0 0 % M
% Asn: 22 0 22 0 0 8 8 8 0 0 15 8 0 8 8 % N
% Pro: 22 8 8 15 0 0 15 0 36 8 0 8 15 8 8 % P
% Gln: 0 0 0 8 0 36 36 0 0 50 0 0 8 8 0 % Q
% Arg: 0 8 0 0 0 0 8 0 0 0 0 15 8 0 15 % R
% Ser: 22 8 8 8 29 0 8 36 0 15 22 0 15 0 8 % S
% Thr: 8 36 8 8 8 0 0 8 0 8 8 0 0 8 0 % T
% Val: 0 0 0 0 8 0 0 8 8 0 0 8 8 43 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _