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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
12.42
Human Site:
S541
Identified Species:
21.03
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
S541
K
K
E
D
K
E
T
S
A
K
R
G
K
E
I
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
S541
K
K
E
D
K
E
T
S
A
K
R
G
K
E
I
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
S541
K
K
E
D
K
E
T
S
A
K
R
G
K
E
I
Dog
Lupus familis
XP_535474
1116
127497
T540
V
K
K
E
D
K
E
T
S
K
R
S
R
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
N511
D
E
R
D
S
T
E
N
Q
H
K
A
K
D
G
Rat
Rattus norvegicus
NP_001099972
1081
122532
E504
A
G
K
T
Q
D
A
E
E
R
D
F
T
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
E539
T
P
E
R
R
P
R
E
A
A
G
A
K
R
Q
Chicken
Gallus gallus
XP_413830
1116
127997
K539
I
K
R
E
Q
E
E
K
E
K
E
K
A
R
K
Frog
Xenopus laevis
NP_001080551
1063
120542
K513
E
M
R
E
L
H
K
K
E
E
I
E
K
K
H
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
L504
W
E
I
Q
K
D
T
L
D
L
M
E
K
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
A358
A
E
I
M
R
D
Q
A
E
F
L
Q
R
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
Q576
E
A
K
A
R
Q
E
Q
R
K
R
T
P
Q
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
P372
S
G
R
N
S
V
A
P
R
A
F
K
T
K
L
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
Q388
P
L
N
H
L
Q
Q
Q
Q
Q
Q
Q
S
D
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
33.3
N.A.
13.3
6.6
N.A.
20
20
6.6
20
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
73.3
N.A.
40
33.3
N.A.
26.6
33.3
33.3
33.3
N.A.
33.3
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
8
0
0
15
8
29
15
0
15
8
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
29
8
22
0
0
8
0
8
0
0
15
0
% D
% Glu:
15
22
29
22
0
29
29
15
29
8
8
15
0
36
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% F
% Gly:
0
15
0
0
0
0
0
0
0
0
8
22
0
0
8
% G
% His:
0
0
0
8
0
8
0
0
0
8
0
0
0
0
8
% H
% Ile:
8
0
15
0
0
0
0
0
0
0
8
0
0
0
29
% I
% Lys:
22
36
22
0
29
8
8
15
0
43
8
15
50
15
22
% K
% Leu:
0
8
0
0
15
0
0
8
0
8
8
0
0
0
8
% L
% Met:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
8
0
0
0
0
0
0
15
% N
% Pro:
8
8
0
0
0
8
0
8
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
8
15
15
15
15
15
8
8
15
0
8
8
% Q
% Arg:
0
0
29
8
22
0
8
0
15
8
36
0
15
15
0
% R
% Ser:
8
0
0
0
15
0
0
22
8
0
0
8
8
0
0
% S
% Thr:
8
0
0
8
0
8
29
8
0
0
0
8
15
0
0
% T
% Val:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _