Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP8 All Species: 32.73
Human Site: Y1016 Identified Species: 55.38
UniProt: P40818 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40818 NP_001122082.1 1118 127523 Y1016 V H L K R F S Y D G R W K Q K
Chimpanzee Pan troglodytes XP_001168710 1118 127532 Y1016 V H L K R F S Y D G R W K Q K
Rhesus Macaque Macaca mulatta XP_001114466 1118 127660 Y1016 V H L K R F S Y D G R W K Q K
Dog Lupus familis XP_535474 1116 127497 Y1014 V H L K R F S Y D G R W K Q K
Cat Felis silvestris
Mouse Mus musculus Q80U87 1080 122592 Y978 V H L K R F S Y D G R W K Q K
Rat Rattus norvegicus NP_001099972 1081 122532 Y979 V H L K R F S Y D G R W K Q K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507996 1116 126304 Y1014 V H L K R F S Y E G R W K Q K
Chicken Gallus gallus XP_413830 1116 127997 Y1014 V H L K R F S Y D G R W K Q K
Frog Xenopus laevis NP_001080551 1063 120542 F962 V H L K R F S F E G R W R Q K
Zebra Danio Brachydanio rerio XP_693811 1099 124389 A980 H L K R X V S A L S S A S V C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650948 896 102648 Y798 D P S N S G S Y M K K Q N Y L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784858 1187 131804 F1089 L L I H L K R F Y Y E G M W R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93Y01 910 102631 F812 L K N K I D T F V N F P V H D
Baker's Yeast Sacchar. cerevisiae P32571 926 105173 F828 N D F V I Y P F L L D L T P F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.3 91.8 N.A. 81.8 81.9 N.A. 76.9 74.4 59.9 53.5 N.A. 31.4 N.A. N.A. 39
Protein Similarity: 100 99.7 99.1 95.3 N.A. 88 87.7 N.A. 87 84.8 74.2 69.5 N.A. 47.7 N.A. N.A. 56.3
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 80 6.6 N.A. 13.3 N.A. N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 13.3 N.A. 20 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 20.2 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 38.3 39.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 8 0 0 0 8 0 0 50 0 8 0 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 0 15 0 8 0 0 0 0 % E
% Phe: 0 0 8 0 0 65 0 29 0 0 8 0 0 0 8 % F
% Gly: 0 0 0 0 0 8 0 0 0 65 0 8 0 0 0 % G
% His: 8 65 0 8 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 8 0 15 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 8 72 0 8 0 0 0 8 8 0 58 0 65 % K
% Leu: 15 15 65 0 8 0 0 0 15 8 0 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % M
% Asn: 8 0 8 8 0 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 0 8 0 0 0 0 8 0 0 0 0 8 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 65 0 % Q
% Arg: 0 0 0 8 65 0 8 0 0 0 65 0 8 0 8 % R
% Ser: 0 0 8 0 8 0 79 0 0 8 8 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % T
% Val: 65 0 0 8 0 8 0 0 8 0 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 65 0 8 0 % W
% Tyr: 0 0 0 0 0 8 0 65 8 8 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _