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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP8
All Species:
25.15
Human Site:
Y679
Identified Species:
42.56
UniProt:
P40818
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40818
NP_001122082.1
1118
127523
Y679
P
T
N
T
V
H
M
Y
P
P
E
M
A
P
S
Chimpanzee
Pan troglodytes
XP_001168710
1118
127532
Y679
P
T
N
T
V
H
M
Y
P
P
E
M
A
P
S
Rhesus Macaque
Macaca mulatta
XP_001114466
1118
127660
Y679
P
T
N
T
V
H
M
Y
P
P
E
M
A
P
S
Dog
Lupus familis
XP_535474
1116
127497
P678
T
N
T
V
H
M
Y
P
P
E
M
A
P
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q80U87
1080
122592
S649
P
P
E
M
A
P
S
S
A
P
P
S
T
P
P
Rat
Rattus norvegicus
NP_001099972
1081
122532
Y642
P
T
N
T
V
H
M
Y
P
P
E
M
A
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507996
1116
126304
Y677
P
T
N
S
V
H
I
Y
P
P
E
M
A
P
P
Chicken
Gallus gallus
XP_413830
1116
127997
Y677
P
T
N
T
V
Q
M
Y
P
P
E
M
A
P
S
Frog
Xenopus laevis
NP_001080551
1063
120542
T651
K
A
K
I
Q
A
H
T
D
T
D
R
E
Q
T
Zebra Danio
Brachydanio rerio
XP_693811
1099
124389
T642
P
E
V
S
T
P
Q
T
P
A
K
H
T
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650948
896
102648
E496
P
S
P
G
R
N
L
E
D
V
H
V
V
S
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784858
1187
131804
D714
S
R
R
Y
F
Y
L
D
H
N
T
S
K
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q93Y01
910
102631
P510
M
P
Y
T
V
I
V
P
K
N
G
S
I
R
D
Baker's Yeast
Sacchar. cerevisiae
P32571
926
105173
A526
N
S
N
G
H
S
S
A
T
S
T
I
Q
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
91.8
N.A.
81.8
81.9
N.A.
76.9
74.4
59.9
53.5
N.A.
31.4
N.A.
N.A.
39
Protein Similarity:
100
99.7
99.1
95.3
N.A.
88
87.7
N.A.
87
84.8
74.2
69.5
N.A.
47.7
N.A.
N.A.
56.3
P-Site Identity:
100
100
100
13.3
N.A.
20
100
N.A.
80
93.3
0
20
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
100
13.3
N.A.
20
100
N.A.
93.3
93.3
13.3
33.3
N.A.
33.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.2
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.3
39.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
8
0
8
8
8
0
8
43
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
15
0
8
0
0
0
15
% D
% Glu:
0
8
8
0
0
0
0
8
0
8
43
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
15
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
15
36
8
0
8
0
8
8
0
0
0
% H
% Ile:
0
0
0
8
0
8
8
0
0
0
0
8
8
0
0
% I
% Lys:
8
0
8
0
0
0
0
0
8
0
8
0
8
0
0
% K
% Leu:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% L
% Met:
8
0
0
8
0
8
36
0
0
0
8
43
0
0
0
% M
% Asn:
8
8
50
0
0
8
0
0
0
15
0
0
0
0
0
% N
% Pro:
65
15
8
0
0
15
0
15
58
50
8
0
8
65
22
% P
% Gln:
0
0
0
0
8
8
8
0
0
0
0
0
8
8
8
% Q
% Arg:
0
8
8
0
8
0
0
0
0
0
0
8
0
8
0
% R
% Ser:
8
15
0
15
0
8
15
8
0
8
0
22
0
15
50
% S
% Thr:
8
43
8
43
8
0
0
15
8
8
15
0
15
8
8
% T
% Val:
0
0
8
8
50
0
8
0
0
8
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
8
8
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _