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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1
All Species:
36.4
Human Site:
S333
Identified Species:
57.2
UniProt:
P40925
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40925
NP_005908.1
334
36426
S333
S
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001163596
334
36422
S333
S
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001084973
344
37589
S343
T
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Dog
Lupus familis
XP_531844
334
36408
S333
T
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
P14152
334
36493
S333
T
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Rat
Rattus norvegicus
O88989
334
36465
S333
T
A
F
E
F
L
S
S
A
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511259
334
36411
S333
T
A
F
E
F
L
T
S
A
_
_
_
_
_
_
Chicken
Gallus gallus
Q5ZME2
334
36525
S333
T
A
V
E
F
L
S
S
A
_
_
_
_
_
_
Frog
Xenopus laevis
Q6PAB3
334
36407
S333
T
A
F
E
F
L
S
S
E
_
_
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_956263
333
36201
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609394
337
36040
S332
E
A
L
S
V
L
D
S
N
V
S
N
L
_
_
Honey Bee
Apis mellifera
XP_394487
333
36140
E332
E
A
K
N
V
L
H
E
K
_
_
_
_
_
_
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796283
335
36178
Q333
D
T
A
N
Q
F
V
Q
P
Q
_
_
_
_
_
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.2
95.2
N.A.
96.4
97
N.A.
91.6
90.4
86.8
78.7
N.A.
65.8
63.4
N.A.
68.3
Protein Similarity:
100
100
96.8
98.1
N.A.
99.4
99.6
N.A.
97.5
96.7
94
89.8
N.A.
77.4
77.2
N.A.
82
P-Site Identity:
100
100
88.8
88.8
N.A.
88.8
88.8
N.A.
77.7
77.7
77.7
0
N.A.
23
22.2
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
88.8
88.8
0
N.A.
23
22.2
N.A.
0
Percent
Protein Identity:
N.A.
61
N.A.
61.6
N.A.
N.A.
Protein Similarity:
N.A.
73.9
N.A.
75.4
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
74
7
0
0
0
0
0
54
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
14
0
0
60
0
0
0
7
7
0
0
0
0
0
0
% E
% Phe:
0
0
54
0
60
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% K
% Leu:
0
0
7
0
0
74
0
0
0
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
14
0
0
0
0
7
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
7
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
14
0
0
7
0
0
54
67
0
0
7
0
0
0
0
% S
% Thr:
47
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% T
% Val:
0
0
7
0
14
0
7
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
67
74
74
74
80
80
% _