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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1
All Species:
33.94
Human Site:
Y210
Identified Species:
53.33
UniProt:
P40925
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40925
NP_005908.1
334
36426
Y210
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Chimpanzee
Pan troglodytes
XP_001163596
334
36422
Y210
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Rhesus Macaque
Macaca mulatta
XP_001084973
344
37589
Y220
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Dog
Lupus familis
XP_531844
334
36408
Y210
Q
G
K
E
V
G
V
Y
D
A
L
K
D
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P14152
334
36493
Y210
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Rat
Rattus norvegicus
O88989
334
36465
Y210
Q
G
K
E
V
G
V
Y
E
A
L
K
D
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511259
334
36411
Y210
Q
G
K
E
V
G
V
Y
E
A
V
K
D
D
S
Chicken
Gallus gallus
Q5ZME2
334
36525
Y210
K
G
K
E
V
G
V
Y
E
A
I
K
D
D
S
Frog
Xenopus laevis
Q6PAB3
334
36407
F210
Q
G
K
D
V
G
A
F
E
A
V
K
N
D
D
Zebra Danio
Brachydanio rerio
NP_956263
333
36201
F210
Q
G
K
D
E
T
A
F
D
A
V
K
D
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609394
337
36040
V210
N
G
T
V
K
S
V
V
D
A
I
N
D
N
G
Honey Bee
Apis mellifera
XP_394487
333
36140
S210
Q
S
S
T
K
P
I
S
L
A
I
N
D
E
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796283
335
36178
V210
N
G
K
K
E
N
V
V
A
A
V
K
N
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
V210
T
S
T
G
E
K
P
V
R
E
L
V
S
D
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
V210
T
S
S
G
E
K
P
V
R
E
L
V
K
D
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.2
95.2
N.A.
96.4
97
N.A.
91.6
90.4
86.8
78.7
N.A.
65.8
63.4
N.A.
68.3
Protein Similarity:
100
100
96.8
98.1
N.A.
99.4
99.6
N.A.
97.5
96.7
94
89.8
N.A.
77.4
77.2
N.A.
82
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
93.3
86.6
60
46.6
N.A.
26.6
20
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
86.6
80
N.A.
46.6
46.6
N.A.
60
Percent
Protein Identity:
N.A.
61
N.A.
61.6
N.A.
N.A.
Protein Similarity:
N.A.
73.9
N.A.
75.4
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
14
0
7
87
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
14
0
0
0
0
20
0
0
0
74
80
27
% D
% Glu:
0
0
0
54
27
0
0
0
54
14
0
0
0
14
0
% E
% Phe:
0
0
0
0
0
0
0
14
0
0
0
0
0
0
0
% F
% Gly:
0
80
0
14
0
60
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
20
0
0
0
0
% I
% Lys:
7
0
74
7
14
14
0
0
0
0
0
74
7
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
7
0
54
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
0
0
0
7
0
0
0
0
0
14
14
7
7
% N
% Pro:
0
0
0
0
0
7
14
0
0
0
0
0
0
0
0
% P
% Gln:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% R
% Ser:
0
20
14
0
0
7
0
7
0
0
0
0
7
0
54
% S
% Thr:
14
0
14
7
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
7
60
0
67
27
0
0
27
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _