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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S3
All Species:
30.91
Human Site:
T115
Identified Species:
52.31
UniProt:
P41091
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41091
NP_001406.1
472
51109
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Chimpanzee
Pan troglodytes
XP_001149413
472
51278
T115
S
M
P
D
E
F
P
T
D
I
P
G
T
K
G
Rhesus Macaque
Macaca mulatta
XP_001089902
472
51065
T115
S
T
P
D
E
F
P
T
D
I
A
G
T
K
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0N1
472
51047
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Rat
Rattus norvegicus
P81795
472
51061
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513184
390
42538
L75
A
V
M
D
A
A
L
L
L
I
A
G
N
E
S
Chicken
Gallus gallus
Q5ZMS3
472
51058
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Frog
Xenopus laevis
NP_001080565
472
51279
T115
S
T
P
D
E
F
P
T
D
I
P
N
T
K
G
Zebra Danio
Brachydanio rerio
NP_997876
472
51302
T115
S
T
P
D
E
F
P
T
D
I
P
G
T
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24208
475
51466
C114
S
K
D
D
S
L
P
C
T
R
L
N
C
S
G
Honey Bee
Apis mellifera
NP_001164640
473
51446
C116
S
K
D
D
S
F
P
C
L
R
P
V
C
S
G
Nematode Worm
Caenorhab. elegans
NP_490960
469
51216
C114
S
T
P
D
R
F
P
C
E
R
A
G
C
G
G
Sea Urchin
Strong. purpuratus
XP_001178408
448
48596
C116
F
P
C
D
R
T
G
C
S
G
K
F
R
L
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32481
527
57847
C174
D
K
E
I
S
P
K
C
Q
R
P
G
C
P
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
99.5
99.7
N.A.
81.3
98.7
96.8
96.4
N.A.
80.4
83.7
73.3
83
Protein Similarity:
100
99.1
99.7
N.A.
N.A.
99.5
99.7
N.A.
82.1
98.9
98
97.8
N.A.
87.1
90
83.9
87.2
P-Site Identity:
100
93.3
93.3
N.A.
N.A.
100
100
N.A.
20
100
93.3
100
N.A.
26.6
40
53.3
6.6
P-Site Similarity:
100
93.3
93.3
N.A.
N.A.
100
100
N.A.
33.3
100
93.3
100
N.A.
26.6
40
60
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
64.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
76
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
8
0
0
0
0
22
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
36
0
0
0
0
29
0
0
% C
% Asp:
8
0
15
93
0
0
0
0
58
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
58
0
0
0
8
0
0
0
0
8
0
% E
% Phe:
8
0
0
0
0
72
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
8
0
72
0
8
86
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
8
0
0
0
0
0
65
0
0
0
0
0
% I
% Lys:
0
22
0
0
0
0
8
0
0
0
8
0
0
58
0
% K
% Leu:
0
0
0
0
0
8
8
8
15
0
8
0
0
8
0
% L
% Met:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
15
8
0
0
% N
% Pro:
0
8
65
0
0
8
79
0
0
0
65
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
15
0
0
0
0
29
0
0
8
0
0
% R
% Ser:
79
0
0
0
22
0
0
0
8
0
0
0
0
15
8
% S
% Thr:
0
58
0
0
0
8
0
58
8
0
0
0
58
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _