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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2S3 All Species: 23.03
Human Site: T21 Identified Species: 38.97
UniProt: P41091 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41091 NP_001406.1 472 51109 T21 H L S R Q D L T T L D V T K L
Chimpanzee Pan troglodytes XP_001149413 472 51278 T21 H L S R Q D L T T L D V T K L
Rhesus Macaque Macaca mulatta XP_001089902 472 51065 T21 H L S R Q D L T T L D V T K L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9Z0N1 472 51047 A21 H L S R Q D L A T L D V T K L
Rat Rattus norvegicus P81795 472 51061 A21 H L S R Q D L A T L D V T K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513184 390 42538
Chicken Gallus gallus Q5ZMS3 472 51058 A21 H L S R Q D L A T L D V T K L
Frog Xenopus laevis NP_001080565 472 51279 A21 H L S R Q D L A T L N V S K L
Zebra Danio Brachydanio rerio NP_997876 472 51302 S21 H L Y K Q D L S T L D V S K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24208 475 51466 S20 N L Q K Q D L S N L D V S K L
Honey Bee Apis mellifera NP_001164640 473 51446 S22 N L Y K Q D L S K L D V S K L
Nematode Worm Caenorhab. elegans NP_490960 469 51216 D20 W L A K Q D L D K V G V D N L
Sea Urchin Strong. purpuratus XP_001178408 448 48596 S22 D L D N L D I S K L N P L S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32481 527 57847 L80 G G L P E Q P L N P D F S K L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 99.7 N.A. N.A. 99.5 99.7 N.A. 81.3 98.7 96.8 96.4 N.A. 80.4 83.7 73.3 83
Protein Similarity: 100 99.1 99.7 N.A. N.A. 99.5 99.7 N.A. 82.1 98.9 98 97.8 N.A. 87.1 90 83.9 87.2
P-Site Identity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 0 93.3 80 73.3 N.A. 60 60 40 20
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 0 93.3 93.3 93.3 N.A. 86.6 86.6 60 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 64.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 76 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 29 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 0 86 0 8 0 0 72 0 8 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 58 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 29 0 0 0 0 22 0 0 0 0 79 0 % K
% Leu: 0 86 8 0 8 0 79 8 0 79 0 0 8 0 86 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 15 0 0 8 0 0 0 0 15 0 15 0 0 8 0 % N
% Pro: 0 0 0 8 0 0 8 0 0 8 0 8 0 0 8 % P
% Gln: 0 0 8 0 79 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 50 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 50 0 0 0 0 29 0 0 0 0 36 8 0 % S
% Thr: 0 0 0 0 0 0 0 22 58 0 0 0 43 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 8 0 79 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _