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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S3
All Species:
48.48
Human Site:
Y238
Identified Species:
82.05
UniProt:
P41091
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41091
NP_001406.1
472
51109
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Chimpanzee
Pan troglodytes
XP_001149413
472
51278
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Rhesus Macaque
Macaca mulatta
XP_001089902
472
51065
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0N1
472
51047
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Rat
Rattus norvegicus
P81795
472
51061
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513184
390
42538
D181
L
I
V
I
R
S
F
D
V
N
K
P
G
C
E
Chicken
Gallus gallus
Q5ZMS3
472
51058
Y238
S
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Frog
Xenopus laevis
NP_001080565
472
51279
Y238
N
I
E
V
V
C
E
Y
I
V
K
K
I
P
V
Zebra Danio
Brachydanio rerio
NP_997876
472
51302
Y238
N
I
E
V
V
C
E
Y
I
V
N
K
I
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24208
475
51466
Y237
N
I
D
V
L
C
E
Y
I
V
N
K
I
P
V
Honey Bee
Apis mellifera
NP_001164640
473
51446
Y239
N
I
E
V
L
C
E
Y
I
T
K
K
I
P
V
Nematode Worm
Caenorhab. elegans
NP_490960
469
51216
Y237
N
V
D
L
V
C
E
Y
L
C
K
K
I
P
V
Sea Urchin
Strong. purpuratus
XP_001178408
448
48596
Y234
N
I
E
V
I
C
E
Y
I
T
K
K
I
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32481
527
57847
F297
N
I
D
A
V
N
E
F
I
V
K
T
I
P
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
99.5
99.7
N.A.
81.3
98.7
96.8
96.4
N.A.
80.4
83.7
73.3
83
Protein Similarity:
100
99.1
99.7
N.A.
N.A.
99.5
99.7
N.A.
82.1
98.9
98
97.8
N.A.
87.1
90
83.9
87.2
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
13.3
93.3
100
93.3
N.A.
80
86.6
66.6
80
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
26.6
100
100
93.3
N.A.
93.3
93.3
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
64.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
76
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
86
0
0
0
8
0
0
0
8
0
% C
% Asp:
0
0
22
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
72
0
0
0
93
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
93
0
8
8
0
0
0
86
0
0
0
93
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
86
86
0
0
0
% K
% Leu:
8
0
0
8
15
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
86
0
0
0
0
8
0
0
0
8
15
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
93
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
15
0
8
0
0
0
% T
% Val:
0
8
8
79
72
0
0
0
8
72
0
0
0
0
86
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _