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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AQP2
All Species:
24.55
Human Site:
S229
Identified Species:
60
UniProt:
P41181
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41181
NP_000477.1
271
28837
S229
V
L
F
P
P
A
K
S
L
S
E
R
L
A
V
Chimpanzee
Pan troglodytes
XP_001157396
268
28320
S226
V
L
F
P
P
A
K
S
L
S
E
R
L
A
V
Rhesus Macaque
Macaca mulatta
XP_001110572
271
28897
S229
V
L
F
P
P
A
K
S
L
S
E
R
L
A
V
Dog
Lupus familis
XP_543678
271
28842
S229
V
L
F
P
P
A
K
S
L
A
E
R
L
A
V
Cat
Felis silvestris
Mouse
Mus musculus
P56402
271
28946
S229
L
L
F
P
S
T
K
S
L
Q
E
R
L
A
V
Rat
Rattus norvegicus
P34080
271
28912
S229
L
L
F
P
S
A
K
S
L
Q
E
R
L
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518393
255
27145
L214
L
F
P
H
A
L
S
L
S
E
R
L
A
T
L
Chicken
Gallus gallus
P28238
262
27053
L221
L
A
A
L
L
Y
E
L
A
L
C
P
R
A
R
Frog
Xenopus laevis
NP_001079331
273
29418
S229
I
F
F
P
H
K
K
S
F
S
D
R
L
A
I
Zebra Danio
Brachydanio rerio
NP_001003534
263
28765
D220
A
M
G
A
L
L
Y
D
F
M
L
F
P
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.5
99.2
95.5
N.A.
88.9
89.6
N.A.
80
52
65.1
55.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
93.3
99.2
98.1
N.A.
94.4
94.8
N.A.
86.3
66.4
80.2
74.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
73.3
80
N.A.
0
6.6
53.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
80
86.6
N.A.
13.3
20
73.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
10
10
50
0
0
10
10
0
0
10
80
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
10
60
0
0
0
0
% E
% Phe:
0
20
70
0
0
0
0
0
20
0
0
10
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
10
70
0
0
0
0
0
0
0
0
% K
% Leu:
40
60
0
10
20
20
0
20
60
10
10
10
70
0
10
% L
% Met:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
70
40
0
0
0
0
0
0
10
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
70
10
10
10
% R
% Ser:
0
0
0
0
20
0
10
70
10
40
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% T
% Val:
40
0
0
0
0
0
0
0
0
0
0
0
0
0
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _